Levetiracetam attenuates spontaneous spike-and-wave discharges in DBA/2J mice
MARROSU, FRANCESCO;FRAU, ROBERTO;PULIGHEDDU, MONICA MARIA FRANCESCA;FA', MAURO;
2007-01-01
Abstract
Recent evidence highlights levetiracetam (LEV) as an advantageous treatment of absence epilepsy (AE). Thus, we investigated the effects of this drug in DBA/2J mice, a murine model of AE. Similarly to ethosuximide (200 mg/kg, intraperitoneal, i.p.) and sodium valproate (250 mg/kg, i.p.), two classic antiabsence agents, LEV (50-200 mg/kg, i.p.) reduced the occurrence of spike-and-wave discharges, AE's typical electroencephalographic patterns. Our results confirm LEV's efficacy in AE treatment. (c) 2007 Elsevier B.V. All rights reserved.Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.