Use of cyclobutyl derivatives as intermediates in the synthesis of 1,2a,3,8b-tetrahydro-2H-cyclobuta[c]chromenes

BERNARD, ANGELA MARIA;FLORIS, COSTANTINO;FRONGIA, ANGELO;Piras PP;SECCI, FRANCESCO

2004-01-01

---

Abstract

Starting from cyclobutanones and tertiary cyclobutanols several new chromenes containing a cyclobutane ring have been prepared by acid catalyzed intramolecular alkylation of an oxygen-carrying aromatic ring. Interestingly one of the cyclobutanols leads to 3-[(4-methoxyphenoxy)methyl]-2,2,3-trimethylcyclopentanone that is a precursor in the synthesis of the carotenoid pigment capsorubin