University of Cagliari
Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids
FAIS, ANTONELLA;ERA, BENEDETTA;DELOGU, GIOVANNA LUCIA
2009-01-01
Abstract
In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3’,4’,5’-trihydroxyphenyl)-6,8-dihydroxycoumarin (8) is the most potent compound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition.
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| File | Size | Format | |
|---|---|---|---|
| Molecules 2009.pdf open access
Type: versione editoriale
Size 243.43 kB
Format Adobe PDF
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243.43 kB | Adobe PDF | View/Open |
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