Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids

FAIS, ANTONELLA;ERA, BENEDETTA;DELOGU, GIOVANNA LUCIA
2009-01-01

Abstract

In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3’,4’,5’-trihydroxyphenyl)-6,8-dihydroxycoumarin (8) is the most potent compound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition.
2009
Inglese
14
7
2514
2520
7
Esperti anonimi
internazionale
scientifica
tyrosinase inhibitors; resveratrol; coumarins
Fais, Antonella; Corda, M; Era, Benedetta; Fadda, Mb; Matos, Mj; Quezada, E; Santana, L; Picciau, C; Podda, G; Delogu, GIOVANNA LUCIA
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
10
open
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