Organocatalytic asymmetric condensation/keto-enol tautomerization tandem reaction:access to cyclobutanone alfa-amino acid ester derivatives

FRONGIA, ANGELO;MELIS, NICOLA;SERRA, ILARIA;SECCI, FRANCESCO;CABONI, PIERLUIGI
2014-01-01

Abstract

A practical method for the synthesis of optically active α-amino cyclobutanones has been developed, via an organocatalytic asym. condensation reaction between racemic 2-hydroxycyclobutanone and chiral N-alkyl-α-amino acid ester derivs.
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