University of Cagliari
Antidopaminergic activity of isoflavone isolated from Butea monosperma flowers
MAXIA, ANDREA;SANNA, CINZIA;
2008-01-01
Abstract
Bioassay guided fractionation of methanolic extract of Butea monosperma flowers was carried out using inhibition of dopamine-induced contraction of rat vas deferens as a biological end point. The antidopaminergic activity was present in the isoflavone isolated from ethyl acetate soluble fraction of methanolic extract. The methanolic extract, its ethyl acetate soluble fraction and the isoflavone potentiated haloperidol-induced catalepsy and inhibited foot shock-induced aggression in rats in a dose dependent manner confirming the antidopaminergic activity.
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