Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties

CONGIU, CENZO;ONNIS, VALENTINA;MORELLI, MICAELA;
2003-01-01

Abstract

A series of amides of ibuprofen with heteroaromatic amines was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to parent ibuprofen some of the new amides exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.
2003
Inglese
38
5
513
518
6
WOS:000183501100007
2-s2.0-0038060514
12767601
http://www.sciencedirect.com/science/article/pii/S0223523403000746
Esperti anonimi
internazionale
scientifica
no
Cocco, Mt; Congiu, Cenzo; Onnis, Valentina; Morelli, Micaela; Cauli, O.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
5
reserved
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