University of Cagliari
Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
NTALLI, NIKOLETTA;COTTIGLIA, FILIPPO;LEONTI, MARCO;BIFULCO, ERSILIA;CABONI, PIERLUIGI
2010-01-01
Abstract
The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
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