Synthesis of new N-(2-(trifluoromethyl)pyridin-4-yl)anthranilic acid derivatives and their evaluation as anticancer agents

COCCO MT;CONGIU, CENZO;LILLIU V;ONNIS, VALENTINA

2004-01-01

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Abstract

The N -(2-(trifluoromethyl)pyridin-4-yl)anthranilic acid 6 and a series of its ester and amide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against human cancer cells. Ester derivatives 13and 18exhibited potent growth inhibitory activity with GI 50 values at nanomolar concentrations. Among amide derivatives, N -anthraniloylglycinate 19shown mod-erate inhibitory activity in the full panel cancer cell line screening.