Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives
CONGIU, CENZO;ONNIS, VALENTINA
2007-01-01
Abstract
A new series of 2-amino-4-aryl-6-dialkylamino-3,5-dicyanopyridines, 20–47, were synthesized in satisfactory overall yield, through a simple synthetic strategy using 3-amino-3-(dialkylamino)-propenenitriles 1 and 2 as key intermediates. 3,5-Dicyanopyridine derivatives 20–47 were evaluated for their in vitro anticancer activity toward cell lines of nine different types of human cancers. Some of the newly prepared compounds demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 106 M level and in some cases at 108 M concentration.Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.