Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity

CONGIU, CENZO;ONNIS, VALENTINA;MORELLI, MICAELA;
2004-01-01

Abstract

A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.
2004
BIOORGANIC & MEDICINAL CHEMISTRY
12
15
4169
4177
9
WOS:000222886700022
15246093
http://www.sciencedirect.com/science/article/pii/S0968089604003852
Esperti anonimi
Original Research Article. L'articolo non dispone di parole chiave
Cocco, Mt; Congiu, Cenzo; Onnis, Valentina; Morelli, Micaela; Felipo, V; Cauli, O.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
6
none
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