Systemic mast cell disease as a rare cause of osteoporosis

CACACE, ENRICO;SALIS G;RUGGIERO, VALERIA;PERPIGNANO G.

2006-01-01

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Abstract

A case of 53 year old woman with a history of a recent onset of weakness, widespread joint and muscle pain, iching, uricaria and lower back pain. Laboratory tests were normal except for markers of bone turnover that were elevated. Bone mineral density showed rarefation of the lumbar spine with normal femoral neck.A bone marrow biopsy taken from the iliac crest was compatible with medullary mastocytosis. The diagnosis of systemic mast cell disease was performed. The patient was treated with neridronate 25 mg i.m. /month for 6 months; skin lesions were managed with ketotifen 10 mg/die. ten months later BMD was increased and markers of bone turnover returned into normal range