Cardiac involvement in patients with lamin A/C gene mutations: a cohort observation

CARBONI, NICOLA;SARDU, CLAUDIA;COCCO, ELEONORA;Marrosu G;Manzi RC;Nissardi V;Isola F;Mateddu A;Solla E;Maioli MA;Oppo V;Piras R;COGHE, GIANCARLO;Lai C;MARROSU, MARIA GIOVANNA

2012-01-01

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Abstract

Introduction: LMNA gene mutations are associated with cardiac and skeletal muscle alterations. Methods: A cohort of 21 mutated individuals was assessed with clinical and instrumental investigations over the years. Results: The median observation period was 6 years. Cardiac compromise was detected in 16 patients. Bradyarrhythmias were the most frequent manifestations, followed by supraventricular arrhythmias. Two individuals suffered from nonsustained and 1 from sustained ventricular tachyarrhythmias. Dilated cardiomyopathy was detected in 3 patients. Evaluation of the frequencies of the clinical expressions showed a high probability of suffering from analogue heart compromise in study subjects bearing the same LMNA gene mutation. Conclusions: Cardiac involvement represents a very common phenotypic expression of LMNA gene mutation. Subjects sharing common genetic background seem to suffer from analogue pattern of cardiac manifestation.