Modulation of 6-hydroxydopamine oxidation by various proteins

PADIGLIA, ALESSANDRA;MEDDA, ROSARIA;Lorrai A;
1997-01-01

Abstract

The spontaneous autoxidation of the neurotoxin 6-hydroxydopamine proceeds by a free radical chain reaction involving the superoxide anion radical and produces the corresponding chromogen 6-hydroxydopamine quinone and hydrogen peroxide. The rate of this reaction is increased in the presence of ceruloplasmin and peroxidase, and reduced by superoxide dismutase, catalase, and DT-diaphorase. We report some explanations of why these proteins may increase or reduce the rate of autoxidation of 6-hydroxydopamine. (C) 1997 Elsevier Science Inc.
1997
BIOCHEMICAL PHARMACOLOGY
53
8
1065
1068
4
WOS:A1997WX88100001
2-s2.0-0030998807
9175710
Esperti anonimi
Padiglia, Alessandra; Medda, Rosaria; Lorrai, A; Biggio, G; Sanna, E; Floris, G.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
6
none
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