High resolution scanning electron microscopy of the intracellular surface of intercalated disks in human heart

Tandler B;Riva L;LOY, FRANCESCO;CONTI, GABRIELE;ISOLA, RAFFAELLA

2006-01-01

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Abstract

The three-dimensional architecture of human cardiac intercalated disks was examined by high resolution scanning electron microscopy of osmium-macerated specimens. This methodology permits viewing of in situ intercalated disks from a vantage point inside individual cardiomyocytes. The erose nature of these structures was rendered in stark relief. Areas covered with clusters of particles were present on some membranous projections-these may represent a combination of desmosomes and fasciae adherentes. On the other hand, areas devoid of particles may correspond to gap junctions.