University of Cagliari
Giulia Costa
Divergent acute and enduring changes in 50-kHz ultrasonic vocalizations in rats repeatedly treated with amphetamine and dopaminergic antagonists: new insights on the role of dopamine in calling behavior
2024-01-01 Serra, Marcello; Costa, Giulia; Onaivi, Emmanuel; Simola, Nicola
Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings
2024-01-01 Serra, Marcello; Simola, Nicola; Pollack, Alexia E; Costa, Giulia
Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice
2023-01-01 Costa, Giulia; Serra, Marcello; Maccioni, Riccardo; Antonietta Casu, Maria; Kasture, Sanjay B.; Acquas, ELIO MARIA GIOACCHINO; Morelli, Micaela
Prenatal and postnatal drug exposure: focus on persistent central effects
2023-01-01 Costa, Giulia; Pollack, Alexia E
Identifying Neurobiological Markers in Obsessive–Compulsive Disorder: A Study Protocol for a Cross-Sectional Study in Subgroups of Differing Phenotype
2023-01-01 Paribello, P.; Carpiniello, B.; Murgia, R.; Porcheddu, A. A.; El-Kacemi, S.; Pinna, F.; Contu, M.; Costa, G.; Barbarossa, R.; Sanna, E.; Carucci, S.; Zuddas, A.; Fadda, P.; Dedoni, S.; Siddi, C.; Congiu, P.; Figorilli, M.; Fanzecco, M.; Puligheddu, M.; Gagliano, A.; Scherma, M.; Manchia, M.
Neurotoxicity of MDMA: Main effects and mechanisms
2022-01-01 Costa, G.; Golembiowska, K.
Protective Agents in Parkinson’s Disease: Caffeine and Adenosine A2A Receptor Antagonists
2021-01-01 Simola, Nicola; Pinna, Annalisa; Frau, Lucia; Costa, Giulia; Marongiu, Jacopo; Parekh, Pathik; Serra, Marcello; Morelli, Micaela
Involvement of the protein ras homolog enriched in the striatum, rhes, in dopaminergic neurons’ degeneration: Link to parkinson’s disease
2021-01-01 Serra, M.; Pinna, A.; Costa, G.; Usiello, A.; Pasqualetti, M.; Avallone, L.; Morelli, M.; Napolitano, F.
Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences
2021-01-01 Costa, G.; Caputi, F. F.; Serra, M.; Simola, N.; Rullo, L.; Stamatakos, S.; Sanna, F.; Germain, M.; Martinoli, M. -G.; Candeletti, S.; Morelli, M.; Romualdi, P.
Association between novel object recognition/spontaneous alternation behavior and emission of ultrasonic vocalizations in rats: Possible relevance to the study of memory
2021-01-01 Costa, G.; Serra, M.; Simola, N.
The Neuroinflammatory and Neurotoxic Potential of Palmitic Acid Is Mitigated by Oleic Acid in Microglial Cells and Microglial-Neuronal Co-cultures
2021-01-01 Beaulieu, J.; Costa, G.; Renaud, J.; Moitie, A.; Glemet, H.; Sergi, D.; Martinoli, M. -G.
Increased emissions of 50-kHz ultrasonic vocalizations in hemiparkinsonian rats repeatedly treated with dopaminomimetic drugs: A potential preclinical model for studying the affective properties of dopamine replacement therapy in Parkinson's disease
2021-01-01 Simola, Nicola; Serra, Marcello; Marongiu, Jacopo; Costa, Giulia; Morelli, Micaela
In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice
2021-01-01 Costa, G.; Spulber, S.; Paci, E.; Casu, M. A.; Ceccatelli, S.; Simola, N.; Morelli, M.
Neuroinflammation and L-dopa-induced abnormal involuntary movements in 6-hydroxydopamine-lesioned rat model of Parkinson's disease are counteracted by combined administration of a 5-HT1A/1B receptor agonist and A2A receptor antagonist
2021-01-01 Pinna, A.; Costa, G.; Serra, M.; Contu, L.; Morelli, M.
Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies
2020-01-01 Costa, Giulia; De Luca, Maria Antonietta; Piras, Gessica; Marongiu, Jacopo; Fattore, Liana; Simola, Nicola
Influence of dopamine transmission in the medial prefrontal cortex and dorsal striatum on the emission of 50-kHz ultrasonic vocalizations in rats treated with amphetamine: Effects on drug-stimulated and conditioned calls
2020-01-01 Costa, Giulia; Serra, Marcello; Marongiu, Jacopo; Morelli, Micaela; Simola, Nicola
Gender Differences in Neurodegeneration, Neuroinflammation and Na+-Ca2+ Exchangers in the Female A53T Transgenic Mouse Model of Parkinson’s Disease
2020-01-01 Costa, Giulia; Sisalli, Maria Jose; Simola, Nicola; Della Notte, Salvatore; Casu, Maria Antonietta; Serra, Marcello; Pinna, Annalisa; Feliciello, Antonio; Annunziato, Lucio; Scorziello, Antonella; Morelli, Micaela
The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats
2019-01-01 Costa, Giulia; Serra, Marcello; Pintori, Nicholas; Casu, Maria Antonietta; Zanda, Mary Tresa; Murtas, Daniela; De Luca, Maria Antonietta; Simola, Nicola; Fattore, Liana
Neuroinflammation and activation of Zif-268 in dyskinetic 6-OHDA-lesioned rats is counteracted by association of a 5-HT1A/1B receptor agonist and an A2A receptor antagonist
2019-01-01 Pinna, A; Costa, G; Serra, M.; Morelli, M
Combined administration of dopaminergic and nondopaminergic drugs reverses neuroinflammation in a rat model of Parkinson’s disease
2019-01-01 Costa, G; Serra, M.; Morelli, M.; Pinna, A
Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age
2019-01-01 Costa, Giulia; Porceddu, Pier Francesca; Serra, Marcello; Casu, Maria Antonietta; Schiano, Valentina; Napolitano, Francesco; Pinna, Annalisa; Usiello, Alessandro; Morelli, Micaela
Modulation of rat 50-kHz ultrasonic vocalizations by glucocorticoid signaling: possible relevance to reward and motivation
2018-01-01 Simola, Nicola; Paci, Elena; Serra, Marcello; Costa, Giulia; Morelli, Micaela
Neurochemical and neurotoxic effects of MDMA (Ecstasy) and caffeine after chronic combined administration in mice
2018-01-01 Górska, Anna Maria; Kamińska, Katarzyna; Wawrzczak-Bargieła, Agnieszka; Costa, Giulia; Morelli, Micaela; Przewłocki, Ryszard; Kreiner, Grzegorz; Gołembiowska, Krystyna
Repeated Administration of 3,4-Methylenedioxymethamphetamine (MDMA) Elevates the Levels of Neuronal Nitric Oxide Synthase in the Nigrostriatal System: Possible Relevance to Neurotoxicity
2018-01-01 Costa, Giulia; Morelli, Micaela; Simola, Nicola
Rhes counteracts dopamine neuron degeneration and neuroinflammation depending on gender and age
2018-01-01 Costa, Giulia; Pinna, Annalisa; Porceddu, Pier Francesca; Casu, Maria Antonietta; Di Maio, Anna; Napolitano, Francesco; Usiello, Alessandro; Morelli, Micaela
NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson's Disease
2018-01-01 Sirabella, Rossana; Sisalli, Maria Josè; Costa, Giulia; Omura, Katia; Ianniello, Gaetano; Pinna, Annalisa; Morelli, Micaela; Di Renzo, Gianfranco Maria; Annunziato, Lucio; Scorziello, Antonella
Emission of categorized 50-kHz ultrasonic vocalizations in rats repeatedly treated with amphetamine or apomorphine: possible relevance to drug-induced modifications in the emotional state
2018-01-01 Simola, Nicola; Costa, Giulia
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms
2017-01-01 Moratalla, Rosario; Khairnar, Amit; Simola, Nicola; Granado, Noelia; García Montes, Jose Ruben; Porceddu, PIER FRANCESCA; Tizabi, Yousef; Costa, Giulia; Morelli, Micaela
Progression and Persistence of Neurotoxicity Induced by MDMA in Dopaminergic Regions of the Mouse Brain and Association with Noradrenergic, GABAergic, and Serotonergic Damage
2017-01-01 Costa, Giulia; Morelli, Micaela; Simola, Nicola
Antidyskinetic effect of A2A and 5HT1A/1B receptor ligands in two animal models of Parkinson's disease
2016-01-01 Pinna, Annalisa; Ko, Wkd; Costa, Giulia; Tronci, Elisabetta; ALVAREZ FIDALGO, Camino; Simola, Nicola; Li, Q; Tabrizi, Ma; Bezard, E; Carta, Manolo; Morelli, Micaela
Methylxanthines and drug dependence: interactions and toxicity
2016-01-01 Costa, Giulia; Morelli, Micaela; Simola, Nicola
The Small GTP-Binding Protein Rhes Influences Nigrostriatal-Dependent Motor Behavior During Aging
2016-01-01 Pinna, Annalisa; Napolitano, F; Pelosi, B; Di Maio, A; Wardas, J; Casu, Ma; Costa, Giulia; Migliarini, S; Calabresi, P; Pasqualetti, M; Morelli, Micaela; Usiello, A.
The small GTP-binding protein Rhes influences midbrain dopaminergic neurons: Behavioral and biochemical studies
2016-01-01 Pinna, A.; Napolitano, F.; Costa, G.; Porceddu, P. F.; Contu, L.; Wardas, J.; Casu, M. A.; Usiello, A.; Morelli, M.
Gender-dependent behavioral and biochemical differences in the A53T genetic mouse model of Parkinson’s disease
2016-01-01 Costa, G.; Sisalli, M. J.; Contu, L.; Scorziello, A.; Morelli, M.
Activation of adenosine A2A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic vocalizations in rats: possible relevance to reward and motivation
2016-01-01 Simola, Nicola; Costa, Giulia; Morelli, Micaela
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent
2016-01-01 Frau, Lucia; Costa, Giulia; Porceddu, Pier Francesca; Khairnar, Amit; Castelli, Maria Paola; Ennas, Maria Grazia; Madeddu, Camilla; Wardas, Jadwiga; Morelli, Micaela
Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates l-DOPA-induced rotational behavior in a rodent model of Parkinson's disease
2015-01-01 Fuzzati Armentero, Mt; Cerri, S; Levandis, G; Ambrosi, G; Montepeloso, E; Antoninetti, G; Blandini, F; Baqi, Y; Muller, Ce; Volpini, R; Costa, Giulia; Simola, Nicola; Pinna, Annalisa
Involvement of Glutamate NMDA Receptors in the Acute, Long-Term, and Conditioned Effects of Amphetamine on Rat 50kHz Ultrasonic Vocalizations
2015-01-01 Costa, Giulia; Morelli, Micaela; Simola, Nicola
Vulnerability to cognitive, neurotoxic and neuroinflammatory effects of toxins that induce Parkinson's disease after administration of amphetamine-related drugs in mice
2014-04-15
MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment and neuroinflammation in the hippocampus and prefrontal cortex
2014-01-01 Costa, Giulia; Simola, Nicola; Morelli, Micaela
L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies
2014-01-01 Pinna, Annalisa; Bonaventura, J; Farre, D; Sanchez, M; Simola, Nicola; Mallol, J; Lluis, C; Costa, Giulia; Baqi, Y; Muller, Ce; Cortes, A; Mccormick, P; Canela, Ei; MARTINEZ PINILLA, E; Lanciego, Jl; Casado', V; Armentero, Mt; Franco, R.
The hypocretin/orexin system mediates the extinction of fear memories
2014-01-01 Flores, A; Valls Comamala, V; Costa, Giulia; Saravia, R; Maldonado, R; Berrendero, F.
Antiparkinsonian actions and interactions of adenosine antagonists
2014-01-01 Morelli, M.; Costa, G.; Pinna, A.
MPTP-induced dopamine neuron degeneration and glia activation is potentiated in MDMA pretreated mice
2013-01-01 Costa, Giulia; Frau, Lucia; Wardas, J; Pinna, A; Plumitallo, Antonio; Morelli, Micaela
Evaluation of drugs acting on CB1-A2A receptor oligomers in rat models of Parkinson's disease
2012-01-01 Simola, N; Costa, G; MULLER C., E; ARMENTERO M., T; Franco, R; Pinna, A.
In vivo antiparkinson activity of drugs acting on A(2A)-CB1-D-2 receptors
2012-01-01 Pinna, A; Costa, G; ARMENTERO M., T; MULLER C., E; Franco, R; Simola, N.
Pharmacological characterization of 50-kHz ultrasonic vocalizations in rats: comparison of the effects of different psychoactive drugs and relevance in drug-induced reward
2012-01-01 Simola, Nicola; Fenu, Sandro; Costa, Giulia; Pinna, Annalisa; Plumitallo, Antonio; Morelli, Micaela
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