NAME: Giovanni Severino, MD

DATE AND PLACE OF BIRTH: August 28, 1965, Cagliari, Italy

STATUS: Married, two children

CITIZENSHIP: Italian

LANGUAGE Italian : writting and speaking (native)
English: writting and speaking (good)
French: writting and speaking (scholar)

ADDRESS: Section of Clinical Pharmacology
Department of Biomedical Science Section of Neurosciences “B.B. Brodie” and Clinical Pharmacology university of Cagliari, Clinical Genetic Unit, Room 1.13 s.p. 8 Monserrato – Sestu Km. 0,700, 09042 Monserrato (CA) Italy +39 070 6754311 (office) 4311 (FAX) (severino@unica.it)

DEGREES

1985 1992 M.D., “magna cum laude”, University of Cagliari, Italy

1982 – 1996 Specialty in Clinical Pharmacology, Faculty of Medicine of the University of Cagliari, Italy

CURRENT APPOINTMENTS
2005 – present Full time researcher at the Department of Biomedical Science Section of Neurosciences and Clinical Pharmacology, Faculty of Medicine of the University of Cagliari, Italy

SUPERVISION ACTIVITY

2008 – present Thesis Supervisor for several students of the School of Medicine, University of Cagliari
2005 – 2009 Co-supervisor of research (Dr. Mirko Manchia at University of Cagliari)
2003 – 2009 Co-supervisor of research (Dr. Alessio Squassina at University of Cagliari)

PAST APPOINTMENTS

1995 (three months)

Visiting scientist at the Clinical Neurogenetics Branch of the National Institute of Mental Health, Bethesda, MD, USA, (supervised by Prof. Elliot S. Gershon)

1997 – 1998

Post doctoral fellow, Department of Psychiatry and Behavioral Sciences School of Medicine John Hopkins University, Baltimore, MD, USA (supervised by Prof. J. R. De Paulo Jr and Francis J. McMahon)

1998 – 2000

Clinical consultant in the scientific project “The Sardinian Affective Disorder and Schizophrenia Study” of the Section of Clinical Pharmacology, Department of Neurosciences “B.B. Brodie”, University of Cagliari in collaboration with the Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs” (LGN) of the Centre Nationale de la Recherche Scientifique (CNRS), Paris, France. (Scientific director Prof. J. Mallet)

2001 – 2005 Research Fellow at the Section of Clinical Pharmacology, Department of Neurosciences “B.B. Brodie”, Faculty of Medicine of the University of Cagliari (supervised by Prof. M Del Zompo)

PROFESSIONAL TRAINING

1984 – 1992 Student of Medicine, University of Cagliari, Italy

1988 Rotating internship in General Surgery at the Unit of Brotzu Hospital via Peretti Cagliari, Italy, University of Cagliari, Italy (6 months)

1989 Rotating internship in Internal Medicine, Department of Medical Science “M. Aresu, University of Cagliari, Italy (6 months)

1990 Rotating internship at the Emergency Unit of Brotzu Hospital via Peretti 1 Cagliari, Italy, University of Cagliari, Italy (4 months)

1990

Rotating internship at the Emergency Unit of San Giovanni Di Dio Hospital Hospital, University of Cagliari and ex ASL 8, Cagliari Italy (4 months)

1990 – 991

Rotating internship at the Pediatric Clinic, University of Cagliari, Cagliari Italy (12 months)

1992

Internship in Psychotherapy, Department of Psychiatry, Faculty of Medicine of the University of Cagliari, Italy (12 months)

1992 1996

Resident in Clinical Pharmacology at the Section of Clinical Pharmacology, Department of Neuroscience “B.B. Brodie”, University of Cagliari-“San Giovanni di Dio” Hospital, Cagliari, Italy
Clinical Psychopharmacology Center: clinical and pharmacological management of out-patients affected by: Bipolar, Major Depressive Recurrent and Anxiety disorders. (Supervised by Maria Del Zompo and Alberto Bocchetta)
Lithium Clinic: therapeutic drug monitoring of mood-stabilizing agents (Supervised by Maria Del Zompo and Alberto Bocchetta)

Parkinson’s Disease Center: Diagnosis and clinical-pharmacological management of patients affected by Parkinson’s Disease and Movement Disorders (Supervised by: Maria Del Zompo)
“Franco Tocco” Headache Centre: Diagnosis and clinical-pharmacological management of patients affected by headaches including migraines, tension headaches and cluster headaches. (Supervised by M. DelZompo)

1996 (12 months)

Genotyping training at the Molecular Genetic Unit Supervised by Maria Paola Piccardi, PhD (Director of the Molecular Genetic Unit at the Section of Clinical Pharmacology, Department of Neurosciences “B.B. Brodie”, Faculty of Medicine of the University of Cagliari, Italy)

1994 (November)

Psychopharmacology course, Neuropsychiatry Department of H. San Raffaele, School of Medicine, University of Milan, Italy (Prof. E Smeraldi)

2000 (March)

SCAN Training Course, supervised by Dr Nicolaou Stylianos, Department of Medicine and Public Health, University of Verona

2001-2004

4-year course at the School of Cognitive Psychotherapy at CESIPC, Florence, Italy, (supervised by Prof. G. Chiari)
1999-2000

Clinical consultant for the project “Emergency Room and Adverse Drug Events”, Italian Society of Pharmacology (Prof. Caputi)

2004 (August)

Advanced Gene Mapping Course, GSF- National Research Center for Environmental Health, Munich, Germany (August 2-6, 2004)

PROFESSIONAL ORGANIZATIONS

1992 – present Italian College of Physicians and Surgeons, General license (# 8471)
2002 – present Member of the International Society of Psychiatric Genetics
2002 – present Member of Italian Association of Constructivist Psychology and Psychotherapy (AIPPC)
2008 – present Member of the Consortium on Lithium Genetics (ConLiGen)
2009 – present Member of the International Society of Bipolar Disorders (ISBD)

RESEARCH ACTIVITY

1. 1994 Best Research Paper, 7° Congresso della Società Italiana di Psichiatria Biologica, S. Margherita di Pula (CA) ITALY, 1994, p. 159, abs. P.31
2. 2001 Best Research Paper, Workshop on: Bipolar Spectrum Disorders: Therapeutic Advances. International Academy for Biomedical and Drug Research, Florence, ITALY
3. 2006 Member of the Local Scientific Committee, XIV World Congress Of Psychiatric Genetics, Cagliari, ITALY, October 28th–November 1st 2006
4. 2009 Invited Guest at the 23rd International Group for the Study of Lithium Treated Patients (IGSLi) Conference in Halifax, Nova Scotia, CANADA by Prof. Martin Alda and IGSLi President Michael Bauer
5. 2010 Invited Guest at the 25rd International Group for the Study of Lithium Treated Patients (IGSLi) Conference in IGSLi, President Michael Bauer
6. 2011 Invited Guest at the 25rd International Group for the Study of Lithium Treated Patients (IGSLi) Conference Lindau, GERMANY by the IGSLi, President Michael Bauer
7. 2013 Invited visiting for a 6-week to the Department of Psychiatry, Dalhousie University in Halifax, Canada as part of the GLOBUS Program
8. 2013 -2014 Sabbatical at the Department of Psychiatry, Dalhousie University Halifax, Canada

LINE OF RESEARCH
Pharmacogenomics, Bipolar Disorder, Lithium, , Adverse Drug Reactions, Genetic of Suicide

COLLABORATIONS

Cooperation Agreement between the Department of Neuroscience “B.B. Brodie”, University of Cagliari (Italy) and the Department of Psychiatry, Dalhousie University, Halifax (Canada): Discovering new potential drug targets: the role of the polyamine system in suicide and lithium mechanism of action http://psychiatry.medicine.dal.ca/research/mood/index.htm, http://www.unica.it/pub/6/index.jsp?is=6&iso=681

Consortium on Lithium Genetics (ConLiGen): international initiative led by National Institute of Mental Health (NIMH) and International Group for The Study of Lithium Treated Patients (IGSLi) to study the genetic basis of response to lithium treatment (http://www.conligen.org/mem-it.html). Affiliate to Pharmacogenomics Research Network (http://pharmgkb.org/contributors/pgrnAffiliates/conligen_profile.jsp)

Pharmacogenomics of Lithium response GWAS study with Dr. George P. Patrinos Assistant Professor, Group leader), Department of Pharmacy, University of Patras, School of Health Sciences, Patras, Greece and Adjunct Assistant Professor, Erasmus MC, Faculty of Medicine, Department of Bioinformatics, Visiting Professor at the Section of Clinical Pharmacology Department of Neuroscience “B.B. Brodie”, University of Cagliari