Curriculum Dr Gabriella Simbula

Education 

1989 – Degree in Biological Sciences, Faculty of di Mathematical, Physical  and  Natural Sciences, University of Cagliari, Italy

1997 – PhD in Molecular and Experimental Pathology, University of Torin, Italy 

Accademic and Scientific Career

1991-1992 - Postgraduate student at  Prof .Columbano e Profssa Ledda-Columbano Institute of Pathology, School of Medicine, University of Cagliari, Itraly

1992 - 1997 - PhD program in “Patologia Sperimentale e Molecolare“ at University of Cagliari and  University of Torino, Italy

1993-1995 – PostDoctoral  Fellow at  Prof. J.L Farber Laboratory Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, USA

1996 – Visiting Post-Doc at Eurpopean Centre for the Validation of Alternative Methods (ECVAM) Ispra (VA), Italy

1996-2000 - Post- Doc at Departiment of Tossicology, Unit of Oncology and Molecular Pathology , University of Cagliari, Italy

2000 –2002 Research Fellow at  Departiment of Tossicology, Unit of Oncology and Molecular Pathology, University of Cagliari, Italy

2002 - Present - Assistant professor at  Departiment of Biomedical Sciences, Section of Pathology, Unit of Oncology and Molecular Pathology  at University of Cagliari, Italy

Teaching Activity 

2002 - Present - Teaching in Molecular and Cellular Pathology,  Toxicology and Quality Control Course at Faculty of Biology and Farmacy, University of Cagliari,  Italy 

Publications

1: Lecca D, Janda E, Mulas G, Diana A, Martino C, Angius F, Spolitu S, Casu MA, Simbula G, Boi L, Batetta B, Spiga S, Carta AR. Boosting phagocytosis and anti-inflammatory phenotyoe in microglia mediates neuroprotection by PPAR ? agonist MDG548 in Parkinson’s disease models. Br J Pharmacol. 2018 Mar 23 Vol.175 (16): 3298-3314
2: Pireddu R, Pibiri M, Valenti D, Sinico C, Fadda AM, Simbula G, Lai F. A novel lactoferrin modified stealth liposome for hepatoma-delivery of triiodothyronine. Int J Pharm. 2018 Feb 15;537(1-2):257-267
3: Tocco G, Zedda G, Casu M, Simbula G, Begala M. Solvent-free addition of indole to aldehydes: unexpected synthesis of novelk 1-[1-(1H-Indol-3yl)alkyl ]-1 indoles and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells  Molecules. 2017 Oct 17; 22(10)1747
4: Mulas G, Espa E, Fenu S, Spiga S, Cossu G, Pillai E, Carboni E, Simbula G, Jadži? D, Angius F, Spolitu S, Batetta B, Lecca D, Giuffrida A, Carta AR. Differential induction of dyskinesia and neuroiflammation by pulsatile versus continuous l-DOPA delivery in the 6-OHDA model of Parkinson’s disease Exp Neurol. 2016 Dec;286:83-92
5: Pisanu A, Lecca D, Mulas G, Wardas J, Simbula G, Spiga S, Carta AR. Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-? agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson’s disease. Neurobiol Dis. 2014 Nov;71:280-91.
6: Cotti E, Petreucic V, Re D, Simbula G. Cytotoxicity evaluation of a new resin-based hybrid root canal sealer: an in vitro study J Endod. 2014 Jan;40(1):124-8.
7: Simbula G, Dettori C, Camboni T, Cotti E. Comparison of tetraacetyleylethylendiamine + sodium perborate and sodium hypochlorite cytotoxicity on L929 fibroblasts J Endod. 2010 Sep;36(9):1516-20.
8:  Perra A, Simbula G, Simbula M, Pibiri M, Kowalik MA, Sulas P, Cocco MT, Ledda-Columbano GM, Columbano A. Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats
FASEB J. 2008 Aug;22(8):2981-9. doi: 10.1096/fj.08-108464. Epub 2008 Apr 23.
9: Perra A, Pibiri M, Sulas P, Simbula G, Ledda-Columbano GM, Columbano A Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in choline-deficient model. Carcinogenesis. 2008 Jan;29(1):161-8.
10: Simbula G, Columbano A, Ledda-Columbano GM, Sanna L, Deidda M, Diana A, Pibiri M. Increased ROS generation and p53activation in alpha-lipoic acid-induced apoptosis in hepatoma cells. Apoptosis 2007 Jan;12(1):113-23.
11. Simbula G, Pibiri M, Sanna L, Cossu C, Molotzu F, Columbano A, Ledda-Columbano GM. The peroxisome proliferator BR931 Kills FaO cells by p53-dependent apoptosis Life Sci. 2004 Jun 4;75(3):271-86.
12. Ledda-Columbano GM, Pibiri M, Molotzu F, Cossu C, Sanna L, Simbula G, Perra A, Columbano A. Induction of hepatocyte proliferation by retinoic acid Carcinogenesis. 2004 Nov; 25(11):2061-66
13. Simbula G, Pibiri M, Sanna L, Cossu C, Molotzu F, Columbano A, Ledda-Columbano GM.
The peroxisome proliferator BR931 Kills FaO cells by p53-dependent apoptosis Life Sci. 2004 Jun 4;75(3):271-8
14. Ledda-Columbano GM, Pibiri M, Concas D, Molotzu F, Simbula G, Cossu C, Columbano A. Sex difference in the proliferative response of mouse hepatocytes to treatment with CAR ligand, TCPOBOP Carcinogenesis. 2003 Jun;24(6):1059-65
15. Ishigami T, Fujita T, Simbula G, Columbano A, Kikuchi K, Ishigami A, Shimosawa T, Arakawa Y, Maruyama N. Regulatory effects of senescence marker protein 30 on the proliferation of the hepatocytes Pathol Int. 2001 Jul;51(7):491-7.
16. Pibiri M, Ledda-Columbano GM, Cossu C, Simbula G, Menegazzi M, Shinozuka H, Columbano A. Cyclin D1 is an early target hepatocyte proliferation induced by thyroid hormone (T3)
FASEB J. 2001 Apr;15(6):1006-13.
17. Simbula G, Glascott PA Jr, Akita S, Hoek JB, Farber JL. Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition
Am J Physiol. 1997 Aug;273(2 Pt 1):C479-88.
18. Pastorino JG, Simbula G, Yamamoto K, Glascott PA Jr, Rothman RJ, Farber JL. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition
J Biol Chem. 1996 Nov 22;271(47):29792-8.
19. Pastorino JG, Simbula G, Gilfor E, Hoek JB, Farber JL. Protoporphyrine IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone J Biol Chem. 1994 Dec 9;269(49):31041-6.
20. Ledda-Columbano GM, Columbano A, Cannas A, Simbula G, Okita K, Kayano K, Kubo Y, Katyal SL, Shinozuka H. Dexametasone inhibits induction of liver tumor necrosis factor-alpha mRNA and liver growth induced by lead nitrate and ethylene dibromide Am J Pathol. 1994 Oct;145(4):951-8.
21. Ledda-Columbano GM, Coni P, Simbula G, Zedda I, Columbano A. Compensatory regeneration, mitogen induced liver growth, and multistage chemical carcinogenesis  Environ Health Perspect. 1993 Dec;101 Suppl 5:163-8.
22. Coni P, Simbula G, de Prati AC, Menegazzi M, Suzuki H, Sarma DS, Ledda-Columbano GM, Columbano A. Differences in the steady-state levels of c-fos, c-jun and c-myc messenger RNA during mitogen-induced liver growth and compensatory regeneration Hepatology. 1993 Jun;17(6):1109-16.
23. Coni P, Pichiri-Coni G, Curto M, Simbula G, Giacomini L, Sarma DS, Ledda-Columbano GM, Columbano A. Different effects of regenerative and direct mitogenic stimuli on the growth ogìf initiated cells in the resistant hepatocyte model Jpn J Cancer Res. 1993 May;84(5):501-7.