Education

1994- Degree in Biological Sciences, Faculty of Mathematical, Physical and Natural Sciences, University of Cagliari

1999- Postgraduate Medical School in Clinical Pathology, University of Sassari

Academic and Scientific Career

1996 to 2000: Postgraduated student at the Department of Toxicology, University of Cagliari. Training in Clinical Pathology.
Visiting fellow  at Biological Chemistry Institute, University of  Verona. 

2000 to 2002: Fellowship from Fondazione Italiana Ricerca sul Cancro (F.I.R.C.). Title of the project “Inhibitory effect of thyroid hormone on chemically induced liver carcinogenesis”.

2002 to present- Assistant Professor of Pathology, University of Cagliari

Teaching activity

2008  General Pathology in Master’s Degree in “Assistenza Sanitaria”, Faculty of Medicine, University of Cagliari)

2008  General Pathology in Master’s Degree in “Ostetricia”, Faculty of Medicine, University of Cagliari

2004-08 General Pathology in Master’s Degree in “Scienze Ortottiche”, Faculty of Medicine, University of Cagliari

2007-08 General Pathology in Master’s Degree in “Ostetricia” and “Assistenza Sanitaria”, Faculty of Medicine, University of Cagliari

2008-09 General Pathology in Master’s Degree in “Ostetricia” and “Assistenza Sanitaria”, Faculty of Medicine, University of Cagliari

2009-10 General Pathology in Master’s Degree in “Ostetricia” and “Assistenza Sanitaria”, Faculty of Medicine, University of Cagliari

2011-12 General Pathology in Master’s Degree in “Ostetricia”, Faculty of Medicine, University of Cagliari

2012-13 General Pathology in Master’s Degree in “Ostetricia”, Faculty of Medicine, University of Cagliari

2014-15 General Pathology in Master’s Degree in “Ostetricia”, “Fisioterapia”, “Riabilitazione psichiatrica”, “Assistenza Sanitaria”, “Tecniche di radiologia medica per immagini e radioterapia”, Faculty of Medicine, University of Cagliari
Clinical Pathology in Master’s Degree in “Ostetricia,” Faculty of Medicine, University of Cagliari

2015-16 General Pathology in Master’s Degree in “Ostetricia”, “Fisioterapia”, “Educazione professionale”, “Assistenza Sanitaria”, “Tecniche di radiologia medica per immagini e radioterapia”, Faculty of Medicine, University of Cagliari
Clinical Pathology in Master’s Degree in “Ostetricia,” Faculty of Medicine, University of Cagliari

2016-17 General Pathology in Master’s Degree in “Ostetricia”, “Fisioterapia”, “Riabilitazione psichiatrica”, “Assistenza Sanitaria”, “Tecniche di radiologia medica per immagini e radioterapia”, Faculty of Medicine, University of Cagliari
Clinical Pathology in Master’s Degree in “Ostetricia,” Faculty of Medicine, University of Cagliari

2017-18 General Pathology in Master’s Degree in “Ostetricia”, “Educazione Professionale”, “Assistenza Sanitaria”, “Tecniche di radiologia medica per immagini e radioterapia”, “Tecniche della prevenzione nell’ambiente e nei luoghi  di lavoro”, Faculty of Medicine, University of Cagliari

2018-19 General Pathology in Master’s Degree in “Ostetricia”, “Educazione Professionale”, “Assistenza Sanitaria”, “Tecniche della prevenzione nell’ambiente e nei luoghi di lavoro”, Faculty of Medicine, University of Cagliari

Publications

1. M.Menegazzi, A.Carcereri, H.Suzuki, H.Shinozuka, M.Pibiri, R.Piga, A.Columbano, G.M.Ledda-Columbano.
Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-?B and AP-1 or expression of tumor necrosis factor-alpha.
Hepatology, 25:585-592, 1997.

2. A.Columbano, G.M.Ledda-Columbano, M.Pibiri, R.Piga, H.Shinozuka, V.De Luca, F.Cerignoli, M.Tripodi.
Increased expression of c-fos, c-jun and LRF-1 is not required for in vivo priming of hepatocytes by the mitogen TCPOBOP.
Oncogene, 14:857-863, 1997.

3. G.M.Ledda-Columbano, A. Perra, R. Piga, M. Pibiri, Loi R., H. Shinozuka, A. Columbano.
Cell proliferation induced by 3,3'-5-triiodo-L-thyronine is associated with a reduction in the number of preneoplastic hepatic lesions.
Carcinogenesis, 20 (12): 2299-2304, 1999

4. G.M. Ledda-Columbano, M. Pibiri, R. Loi, A. Perra, H. Shinozuka, A. Columbano.
Early increase in cyclin D1 expression and accelerated entry of mouse hepatocytes into S phase after administration of the mitogen TCPOBOP.
American Journal of Pathology, 156 (1): 91-97, 2000

5. G.M. Ledda-Columbano, M. Pibiri, A. Perra, R. Piga, R. Loi, M. Dore, H. Shinozuka, A. Columbano
Ciprofibrate and triiodothyronine do not suppress in vivo induction of placental glutathione S-transferase expression in rat hepatocytes.
Cancer Letters, 151: 153-159, 2000

6.  M. Pibiri, G.M. Ledda-Columbano, C. Cossu, G. Simbula, M. Menegazzi, H. Shinozuka, A. Columbano
Cyclin D1 is an early target in hepatocyte proliferation induced by thyroid hormone (T3).
The FASEB J., 15: 1006-1013, 2001

7. A. Columbano, G.M. Ledda-Columbano, M. Pibiri, D. Concas, J.K. Reddy, M.S. Rao
Peroxisome proliferator activated receptor-alpha -/- mice show enhanced hepatocyte proliferation in response to the hepatomitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a ligand of constitutive androstane receptor.
Hepatology,34:262-266, 2001

8. G.M. Ledda-Columbano, M. Pibiri, D. Concas, C. Cossu, M. Tripodi, A. Columbano.
Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli.
Hepatology, 36:1098-1105, 2002

9. G.M. Ledda-Columbano, M. Pibiri, D. Concas, F. Molotzu, G. Simbula, C. Cossu and A.  Columbano.
Sex difference in the proliferative response of mouse hepatocytes to treatment with the CAR ligand, TCPOBOP.
Carcinogenesis,Vol 24, NO. 7 : 1-7, 2003

10. G. Simbula, M. Pibiri, L. Sanna, C. Cossu, F. Molotzu, A. Columbano, G.M. Ledda-Columbano.
The peroxisome proliferator BR931 Kills FaO cells by p53-dependent apoptosis.
Life Sciences, 75 (3):271-268, Jun 4, 2004

11. Ledda-Columbano G. M., Pibiri M., Cossu C., Molotzu F., Locker J., Columbano A.
Aging does not reduce the hepatocyte proliferative response of  mice to the primary mitogen TCPOBOP.
Hepatology, 40 (4): 981-8, Oct 2004

12. Ledda-Columbano GM, Pibiri M, Molotzu F, Cossu C, Sanna L, Simbula G, Perra A, Columbano A.
Induction of hepatocyte proliferation by retinoic acid.
Carcinogenesis, 25 (11): 2061-6 , Nov 2004

13. GM Ledda-Columbano, A Perra, M Pibiri, F Molotzu and A Columbano.
Induction of pancreatic acinar cell proliferation by thyroid hormone.
Journal of Endocrinology, 185, 393-399, 2005

14. A Columbano, G.M. Ledda-Columbano, M. Pibiri, C. Cossu, M. Menagazzi, D.D. Moore, W. Huang, J. Tian and J. Locker.
GADD45β is induced through a CAR-dependent TNF-independent pathway in murine liver hyperplasia.
Hepatology, 42, 1118-1126, 2005

15. G.M. Ledda-Columbano, F. Molotzu, M. Pibiri, C. Cossu, A. Perra and A. Columbano.
Thyroid hormone induces cyclin D1 nuclear traslocation and DNA synthesis in adult rat cardiomyocites.
FASEB J. ,20, 87-94, 2006

16. A Columbano, M Pibiri, M Deidda, C Cossu, TS Scanlan, G Chiellini, S Muntoni, GM Ledda-Columbano.
The thyroid hormone receptor-? agonist GC-1 induces cell proliferation in rat liver and pancreas.
Endocrinology 147 (7): 3211-3218, 2006

17. Simbula G, Columbano A, Ledda-Columbano GM, Sanna L, Deidda M, Diana A, Pibiri M
Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.
Apoptosis. Jan;12(1):113-23, 2007

18. Perra A, Pibiri M, Sulas P, Simbula G, Ledda-Columbano GM, Columbano A.
Alpha-lipoic acid promotes the growth of rat hepatic preneoplastic lesions in the coline-deficient  model.
Carcinogenesis, 2007 Jan;29(1):161-8.

19. Columbano A, Simbula M, Pibiri M, Perra A, Deidda M, Locker J, Pisanu A, Uccheddu A, Ledda-Columbano GM.
Triiodothyronine stimulates hepatocyte proliferation in two models of impaired liver regeneration.
Cell Proliferation, 2008 Jun;41(3):521-31.

20. Columbano A, Simbula M, Pibiri M, Perra A, Pisanu A, Uccheddu A, Ledda-Columbano GM.
Potential utility of xenobiotic mitogens in the context of liver regeneration in the elderly and living-related transplantation.
Lab Investigation, 2008 Apr;88(4):408-15.

21. Perra A, Simbula G, Simbula M, Pibiri M, Kowalik MA, Sulas P, Cocco MT, Ledda-  Columbano GM, Columbano A.
Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats.
FASEB J. Aug; 22(8):2981-9, 2008

22. Perra A, Kowalik MA, Pibiri M, Ledda-Columbano GM, Columbano A.
Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype.
Hepatology. Apr; 49(4):1287-96, 2009

23. Kowalik MA, Perra A, Pibiri M, Cocco MT, Samarut J, Plateroti M, Ledda-Columbano GM, Columbano A.
TRbeta is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cell.
J Hepatol. Oct;53(4):686-92, 2010

24. Kowalik MA, Saliba C, Pibiri M, Perra A, Ledda-Columbano GM, Sarotto I, Ghiso E, Giordano S, Columbano A
Yes-associated protein regulation regulation of adaptive liver enlargement and HCC     development.
Hepatology. Jun;53(6):2086-96, 2011

25. Leoni VP, Ledda-Columbano GM, Pibiri M, Saliba C, Perra A, Kowalik MA, Grober OM,  Ravo M, Weisz A, Locker J, Ghiso E, Giordano S, Columbano A.
Expression of C-Jun is Not Mandatory for Mouse Hepatocyte Proliferation Induced by Two  Nuclear Receptor Ligands: Tcpobop and T3,
J Hepatol. Nov;55(5):1069-78, 2011.

26. Zedda G, Simbula G, Begala M, Pibiri M, Floris C, Casu M, Casu L, Tocco G
Mild Synthetic Approach to Novel Indole-1-Carbinois and Preliminary Evaluation of Their Cytotoxicity in Hepatocarcinoma Cells.
Arch Pharm (Weinheim). Mar;345(3):195-202, 2012

27. Pibiri M, Sulas P, Leoni VP, Perra A, Kowalik MA, Cordella A, Saggese P, Nassa G, Ravo M.
Global gene expression profile of normal and regenerating liver in young and old mice.
Age. June;37(3):9697, 2015

28. Szydlowska M, Pibiri M, Perra A, Puliga E, Mattu S, Ledda-Columbano GM, Columban A, Leoni VP.
The Thyromimetic KB2115 (Eprotirome) Induces Rat Hepatocyte Proliferation.
Gene Expr Jul 7;17(3):207-218, 2017

29. Pireddu R, Pibiri M, Valenti D, Sinico C, Fadda AM, Simbula G, Lai F.
A novel lactoferrin-modified stealth liposome for hepatoma-delivery of triiodothyronine.
Int J Pharm. Feb 15;537(1-2):257-267, 2018

30. Pibiri M, Leoni VP, Atzori L.
Heme oxygenase-1 inhibitor tin-protoporphyrin improves liver regeneration after partial hepatectomy.
Life Sci. Jul 1;204:9-14, 2018

31. Pibiri M.
Liver regeneration in aged mice: new insights.
Aging (Albany NY). Aug 28, 2018 doi: 10.18632/aging/101524

32. Tronci L, Caria P, Frau DV, Liggi S, Piras C, Murgia F, Santoru ML, Pibiri M, Deiana M, Griffin JL, Vanni R, Atzori L.
Crosstalk between Metabolic Alterations and Altered Redox Balance in PTC-Derived Cell Lines.
Metabolites. Feb 1;9(2), 2019 doi: 10.3390/metabo9020023