University of Cagliari
Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model
2015-01-01 Lattanzi, R; Maftei, D; Marconi, V; Florenzano, F; Franchi, S; Borsani, E; Rodella, Lf; Balboni, Gianfranco; Salvadori, S; Sacerdote, P; Negri, L.
Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity
2015-01-01 Congiu, Cenzo; Onnis, Valentina; Deplano, Alessandro; Balboni, Gianfranco; Dedeoglu, Nurcan; Supuran, Claudiu T.
A novel mechanism for cytoprotection against hypoxic injury: delta-opioid receptor-mediated increase in Nrf2 translocation
2015-01-01 Cao, S; Chao, D; Zhou, H; Balboni, Gianfranco; Xia, Y.
Inhibitory effect of positively charged triazine antagonists of prokinecitin receptors on the transient receptor vanilloid type-1 (TRPV1) channel
2015-01-01 Petrocellis, Luciano De; Moriello, Aniello Schiano; Byun, Joon Seok; Sohn, Joo Mi; Lee, Jae Yeol; Vázquez Romero, Ana; Garrido, Maria; Messeguer, Angel; Zhang, Fang Xiong; Zamponi, Gerald W; Deplano, Alessandro; Congiu, Cenzo; Onnis, Valentina; Balboni, Gianfranco; Marzo, Vincenzo Di
PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice
2015-01-01 Guida, F; Lattanzi, R; Boccella, S; Maftei, D; Romano, R; Marconi, V; Balboni, Gianfranco; Salvadori, S; Scafuro, Ma; DE NOVELLIS, V; Negri, L; Maione, S; Luongo, L.
Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity
2015-01-01 Severini, C.; Lattanzi, R.; Maftei, D.; Marconi, V.; Ciotti, M. T.; Petrocchi Passeri, P.; Florenzano, F.; Del Duca, E.; Caioli, S.; Zona, C.; Balboni, Gianfranco; Salvadori, S.; Nistico, R.; Negri, L.
Design, Synthesis and Evaluation of new 2-(Arylidenehydrazino)pyrrole Derivatives as Potential Antitumor Agents
2014-01-01 Congiu, Cenzo; Onnis, Valentina; Deplano, Alessandro; Demurtas, M; Balboni, Gianfranco
Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals
2014-01-01 Maftei, D; Marconi, V; Florenzano, F; Giancotti, La; Castelli, M; Moretti, S; Borsani, E; Rodella, Lf; Balboni, Gianfranco; Luongo, L; Maione, S; Sacerdote, P; Negri, L; Lattanzi, R.
An important role for prokineticin 2 in autoimmune CNS demyelination
2014-01-01 Abou hamdan, M.; Costanza, M.; Fontana, E.; Musio, S.; Di Dario, M.; Congiu, Cenzo; Onnis, Valentina; Lattanzi, R.; Negri, L.; Poliani, P. L.; Farina, C.; Balboni, Gianfranco; Steinman, L.; Pedotti, R.
Antidepressant-like and anxiolytic-like effects following activation of the mu-delta opioid receptor heteromer in the nucleus accumbens
2014-01-01 Kabli, N; Nguyen, T; Balboni, Gianfranco; O'Dowd, Bf; George, S.
New insights into the machanism of PPAR gamma regulation of trophoblast invasion and placental vascularization.
2014-01-01 Garnier, V; Traboulsi, W; Brouillet, S; Sergent, F; Fournier, T; Zhou, Qy; Balboni, Gianfranco; Desvergne, B; Hoffmann, P; Feige, Jj; Alfaidy, N.
Interaction and reactivity of synthetic aminoisoflavones with metal-free and metalassociated amyloid-beta
2014-01-01 Detoma, As; Krishnamoorthy, J; Nam, Y; Lee, Hj; Brender, Jr; Kochi, A; Lee, D; Onnis, Valentina; Congiu, Cenzo; Manfredini, S; Vertuani, S; Balboni, Gianfranco; Ramamoorthy, A; Lim, Mh
Halogenated triazinediones behave as antagonists of PKR1: in vitro and in vivo pharmacological characterization
2014-01-01 Lattanzi, R; Congiu, Cenzo; Onnis, Valentina; Deplano, Alessandro; Salvadori, S; Marconi, V; Maftei, D; Francioso, A; Ambrosio, C; Casella, I; Costa, T; Caltabiano, G; Matsoukas M., T; Balboni, Gianfranco; Negri, L.
δ‐Opioid receptors up‐regulate excitatory amino acid transporters in mouse astrocytes
2014-01-01 Liang, J; Dongman, C; Sandhu, Hk; Yu, Y; Zhang, L; Balboni, Gianfranco; Kim, Dh; Xia, Y.
Ligand- and cell-dependent determinants and cAMP modulation by delta opioid receptor (DOR) agonists
2014-01-01 Charfi, I; Nagi, K; MNIE FILALI, O; Thibault, D; Balboni, Gianfranco; Schiller, Pw; TRUDEAU L., E; Pineyro, G.
A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists
2014-01-01 Congiu, Cenzo; Onnis, Valentina; Deplano, Alessandro; Salvadori, S; Marconi, V; Maftei, D; Negri, L; Lattanzi, R; Balboni, Gianfranco
Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties
2014-01-01 Congiu, Cenzo; Onnis, Valentina; Balboni, Gianfranco; Supuran, Ct
Conformational dynamics of KIR3.1/KIR3.2 channel activation via delta-opioid receptors (DORs)
2013-01-01 RICHARD LALONDE, M; Nagi, K; Audet, N; Sleno, R; Amraei, M; Hogue, M; Balboni, Gianfranco; SCHILLER P., W; Bouvier, M; HÉBERT T., E; Pineyro, G.
Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues
2013-01-01 Lesma, G; Salvadori, S; Airaghi, F; Bojnik, E; Borsodi, A; Recca, T; Sacchetti, A; Balboni, Gianfranco; Silvani, A.
Structural and biological exploration of Phe3-Phe4-modified endomorphin-2 peptidomimetics
2013-01-01 Lesma, G; Salvadori, S; Airaghi, F; Murray, Tf; Recca, T; Sacchetti, A; Balboni, Gianfranco; Silvani, A.
Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors
2013-01-01 Vezzi, V; Onaran, Ho; Molinari, P; Guerrini, R; Balboni, Gianfranco; Calo', G; Costa, T.
activation of the mu-delta opioid receptor heteromer produces anti-depressant-like and anxiolytic-like effects
2013-01-01 Kabli, N; Nguyen, T; Balboni, Gianfranco; O'Dowd, Bf; George, Sr
Delta-opioid receptor activation modified microRNA expression in the rat kidney under prolonged hypoxia
2013-01-01 He, X; Yang, Y; Zhi, F; Moore, Ml; Kang, X; Chao, D; Wang, R; Balboni, Gianfranco; Salvadori, S; Kim, Hd; Xia, Y.
Effect of delta-opioid receptor activation on BDNF-TrkB vs. TNF-Alpha in the mouse cortex exposed to prolonged hypoxia
2013-01-01 Tian, X; Hua, F; SANDHU H., K; Chao, D; Balboni, Gianfranco; Salvadori, S; He, X; Xia, Y.
Design, Synthesis, Biological Activity and SAR of New FAAH Inhibitors
2012-01-01 Onnis, Valentina; Congiu, Cenzo; Balboni, Gianfranco; Fowler, Cj
New antiproliferative diarylpyridines. design, synthesis, biological and photophysical characterization
2012-01-01 Congiu, Cenzo; Balboni, Gianfranco; Onnis, Valentina; Viola, G; Porcù, E; Vázquez, Me; Pazos, E.
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins
2012-01-01 Balboni, Gianfranco; Congiu, Cenzo; Onnis, Valentina; Maresca, A; Scozzafava, A; Winum, Jy; Maietti, A; Supuran, Ct
Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues.
2012-01-01 Silvani, A; Airaghi, F; Balboni, Gianfranco; Bojnik, E; Borsodi, A; Lesma, G; Salvadori, S; Recca, T; Sacchettie, A.
DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex
2012-01-01 Chao, D; He, X; Yang, Y; BAZZY ASAAD, A; Lazarus, Lh; Balboni, Gianfranco; Kim, Dh; Xia, Y.
The prokineticin system in experimental autoimmune encephalomyelitis: Possible novel targets for immune intervention.
2012-01-01 ABOU HAMDAN, M; Costanza, M; Musio, S; Fontana, E; Balboni, Gianfranco; Pedotti, R.
Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex
2012-01-01 Chao, D; He, X; Yang, Y; Balboni, Gianfranco; Salvadori, S; Dong, Kh; Xia, Y.
Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context
2012-01-01 Wall, Rj; He, G; Denison, Ms; Congiu, Cenzo; Onnis, Valentina; Fernandes, A; Bell, Dr; Rose, M; Rowlands, Jc; Balboni, Gianfranco; Mellor, I. R.
Synthesis and Carbonic Anhydrase Inhibitory Activity of New 2-Aminochromenone Derivatives
2011-01-01 Congiu, Cenzo; Onnis, Valentina; Balboni, Gianfranco; Innocenti, A; Supuran, C. T.
Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic
2011-01-01 Balboni, Gianfranco; Salvadori, S; MARCZAK E., D; KNAPP B., I; BIDLACK J., M; LAZARUS L., H; Peng, X; SI Y., G; Neumeyer, J. L.
Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain
2011-01-01 Jacobson, O; Weiss, Id; Niu, G; Balboni, Gianfranco; Congiu, Cenzo; Onnis, Valentina; Kiesewetter, Do; Lattanzi, R; Salvadori, S; Chen, X.
Prokineticin receptors antagonist PC-10 as a biomarker for imaging inflammatory pain
2010-01-01 Jacobson, O; Weiss, I; Balboni, Gianfranco; Chen, X.
Synthesis and biological activity of prokineticin receptors antagonists and their development as a biomarker for imaging inflammatory pain
2010-01-01 Congiu, Cenzo; Onnis, Valentina; Balboni, Gianfranco; Salvadori, S; Negri, L; Lattanzi, R; Jacobson, O; WEISS I., D; Niu, G; Chen, X.
Evolution of the bifunctional lead mu agonist / delta antagonist containing the 2',6'-dimethyl-L-tyrosine-1,2,3,4-tetrahydroisoquinoline-3.carboxylic acid (Dmt-Tic) opioid pharmacophore
2010-01-01 Balboni, Gianfranco; Salvadori, S; Trapella, C; KNAPP B., I; BIDLACK J., M; LAZARUS L., H; Peng, X; Neumeyer, J. L.
Role of the 2',6'-dimethyl-L-tyrosine (Dmt) in some opioid lead compounds
2010-01-01 Balboni, Gianfranco; Marzola, E; Sasaki, Y; Ambo, A; MARCZAK E., D; LAZARUS L., H; Salvadori, S.
Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds
2010-01-01 Ballet, S; MARCZAK E., D; Feytens, D; Salvadori, S; Sasaki, Y; ABELL A., D; LAZARUS L., H; Balboni, Gianfranco; Tourwe', D.
Agonists at the delta-opioid receptor modify the binding of mu-receptor agonists to the mu-delta receptor hetero-oligomer
2010-01-01 Kabli, N; Martin, N; Fan, T; Nguyen, T; Hasbi, A; Balboni, Gianfranco; O'DOWD B., F; George, S. R.
Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice
2009-01-01 MARCZAK E., D; Jinsmaa, Y; MYERS P., H; Blankenship, T; Wilson, R; Balboni, Gianfranco; Salvadori, S; Lazarus, L. H.
Na+ mechanism of delta-opioid receptor induced protection from K+ leakage in the cortex
2009-01-01 Chao, D; Balboni, Gianfranco; LAZARUS L., H; Salvadori, S; Xia, Y.
Delta-opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation
2009-01-01 Kang, X; Chao, D; Gu, Q; Ding, G; Wang, Y; Balboni, Gianfranco; LAZARUS L., H; Xia, Y.
The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain
2009-01-01 Giannini, E; Lattanzi, R; Nicotra, A; CAMPESE A., F; Grazioli, P; Screpanti, I; Balboni, Gianfranco; Salvadori, S; Sacerdote, P; Negri, L.
Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore
2009-01-01 Balboni, Gianfranco; Trapella, C; Sasaki, Y; Ambo, A; MARCZAK E., D; LAZARUS L., H; Salvadori, S.
Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold
2009-01-01 Ballet, S; Feytens, D; DE WACHTER, R; DE VLAEMINCK, M; MARCZAK E., D; Salvadori, S; DE GRAAF, C; Rognan, D; Negri, L; Lattanzi, R; LAZARUS L., H; Tourwe', D; Balboni, Gianfranco
Fluorine-substituted 2',6'-dimethyl-L-tyrosine-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid peptides (Dmt-Tic) for use as myu- and delta-opioid receptors probes in
2008-01-01 LAZARUS L., H; Balboni, Gianfranco; Salvadori, S; Chen, X.
Delta-opioid receptor induced inhibition of sodium channel function
2008-01-01 KANG XUE, Zhi; GU QUAN, Bao; DING GUANG, Hong; CHAO DONG, Man; WANG YING, Wei; Balboni, Gianfranco; LAZARUS L., H; Xia, Ying
Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist
2008-01-01 Vergura, R; Balboni, Gianfranco; Spagnolo, B; Gavioli, E; LAMBERT D., G; Mcdonald, J; Trapella, C; LAZARUS L., H; Regoli, D; Guerrini, R; Salvadori, S; Calo', G.
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