Inhibition of the development of morphine tolerance by a potent dual mu- / delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph
2008-01-01 Jinsmaa, Y; MARCZAK E., D; Balboni, Gianfranco; Salvadori, S; Lazarus, L. H.
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging
2008-01-01 RYU E., K; Wu, Z; Chen, K; LAZARUS L., H; MARCZAK E., D; Sasaki, Y; Ambo, A; Salvadori, S; Ren, C; Zhao, H; Balboni, Gianfranco; Chen, X.
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic
2008-01-01 Balboni, Gianfranco; Fiorini, S; Baldisserotto, A; Trapella, C; Sasaki, Y; Ambo, A; MARCZAK E., D; LAZARUS L., H; Salvadori, S.
Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex
2008-01-01 Chao, D; BAZZY ASAAD, A; Balboni, Gianfranco; Salvadori, S; Xia, Y.
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502)
2008-01-01 Salvadori, S; Fiorini, S; Trapella, C; Porreca, F; Davis, P; Sasaki, Y; Ambo, A; MARCZAK E., D; LAZARUS L., H; Balboni, Gianfranco
Triazine compounds as antagonists at Bv8-prokineticin receptors
2008-01-01 Balboni, Gianfranco; Lazzari, I; Trapella, C; Negri, L; Lattanzi, R; Giannini, E; Nicotra, A; Melchiorri, P; Visentin, S; DE NUCCIO, C; Salvadori, S.
Biologically potent analogues of the Dmt-Tic pharmacophore and methods of use
2007-01-01 LAZARUS L., H; Balboni, Gianfranco; Salvadori, S.
Delta-, but not mu-, opioid receptor stabilize K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia
2007-01-01 Chao, D; BAZZY ASAAD, A; Balboni, Gianfranco; Xia, Y.
In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist, correlation between desensitization and tolerance
2007-01-01 Aguila, B; Coulbault, L; Boulouaerd, M; Leveille, F; Davis, A; Toth, G; Borsodi, A; Balboni, Gianfranco; Salvadori, S; Jauzac, P; Allouche, S.
A new opioid designed multiple ligand derived from the mu opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic
2007-01-01 Salvadori, S; Trapella, C; Fiorini, S; Negri, L; Lattanzi, R; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Balboni, Gianfranco
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore
2007-01-01 Balboni, Gianfranco; Onnis, Valentina; Congiu, Cenzo; Zotti, M; Sasaki, Y; Ambo, A; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Lazzari, I; Trapella, C; Salvadori, S.
Dimethyltyrosine, the Viagra of Opioids
2006-01-01 Lazarus, L. H.; Bryant, S. D.; Salvadori, S.; Guerrini, R.; Balboni, Gianfranco; Tsuda, Y.; Okada, Y.
Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test amd regulate BDNF mRNA expression in rats
2006-01-01 TORREGROSSA M., M; JUTKIEWICZ E., M; MOSBERG H., I; Balboni, Gianfranco; WATSON S., J; Woods, J. H.
6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in delta- and mu-Selective Opioid Peptides
2006-01-01 VAZQUEZ M., V; BLANCO J., B; Salvadori, S; Trapella, C; Argazzi, R; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Negri, L; Giannini, E; Lattanzi, R; Colucci, M; Balboni, Gianfranco
Dmt-Tic-NH-CH2-Bid (UFP-502), a Potent DOP Receptor Agonist; In Vitro and in Vitro Studies
2006-01-01 Vergura, R; Valenti, E; HEBBES C., P; GAVIOLI E., C; Spagnolo, B; Mcdonald, J; LAMBERT D., G; Balboni, Gianfranco; Salvadori, S; Regoli, D; Calo', G.
New Opioid Designed Multiple Ligand from Dmt-Tic and Morphinan Pharmacophores
2006-01-01 NEUMEYER J., L; Peng, X; KNAPP B., I; BIDLACK J., M; LAZARUS L., H; Salvadori, S; Trapella, C; Balboni, Gianfranco
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore
2006-01-01 Balboni, Gianfranco; Onnis, Valentina; Congiu, Cenzo; Zotti, M; Sasaki, Y; Ambo, A; Bryant, Sd; Jinsmaa, Y; Lazarus, Lh; Trapella, C; Salvadori, S.
New 2',6'-Dimethyl-L-Tyrosine (Dmt) Opioid Peptidomimetics Based on the Aba-Gly Scaffold. Development of Unique mu-Opioid Ligands
2006-01-01 Ballet, S; Salvadori, S; Trapella, C; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Negri, L; Giannini, E; Lattanzi, R; Tourwe', D; Balboni, Gianfranco
Biologically potent analogues of the Dmt-Tic pharmacophore and methods of use
2005-01-01 LAZARUS L., H; Salvadori, S; Balboni, Gianfranco; Guerrini, R.
From the potent and selective mu opioid receptor agonist H-Dmt-D-Arg-Phe-Lys-NH2 to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH
2005-01-01 Balboni, Gianfranco; Cocco, M. T.; Salvadori, S.; Romagnoli, R.; Sasaki, Y.; Okada, Y.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H.
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH2-Bid into delta-opioid antagonists by N1-benzimidazole alkylation
2005-01-01 Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Negri, L.; Giannini, E.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H.
Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism
2004-01-01 Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Negri, L.; Giannini, E.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H.
Synthesis of N-FmocN,N'-bis-Boc-5-,6- and 8-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid (5-GTIC, 6-GTIC and 8-GTIC)
2004-01-01 Severino, B; Santagada, V; Frecentese, F; Perissutti, E; Terracciano, S; Fiorino, F; Cirillo, D; Salvadori, S; Balboni, Gianfranco; Caliendo, G.
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic
2004-01-01 Balboni, Gianfranco; Salvadori, S.; DAL PIAZ, A.; Bortolotti, F.; Argazzi, R.; Negri, L.; Lattanzi, R.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H.
Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism
2003-01-01 Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Negri, L.; Giannini, E.; Bryant, S. D.; Jinsmaa, Y; Lazarus, L. H.
POTENT DELTA-OPIOID RECEPTOR AGONISTS CONTAINING THE DMT-TIC PHARMACOPHORE
2002-01-01 Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Negri, L.; Giannini, E.; Jinsmaa, Y.; Bryant, S. D.; Lazarus, L. H.
CRYSTAL STRUCTURES OF DIPEPTIDES CONTAINING THE DMT-TIC PHARMACOPHORE
2002-01-01 Bryant, S. D.; George, C.; FLIPPEN ANDERSON, J. L.; Deschamps, J. R.; Salvadori, S.; Balboni, Gianfranco; Guerrini, R.; Lazarus, L. H.
EVALUATION OF THE DMT-TIC PHARMACOPHORE: CONVERSION OF A POTENT DELTA-OPIOID RECEPTOR ANTAGONIST INTO A POTENT DELTA AGONIST AND LIGANDS WITH MIXED PROPERTIES
2002-01-01 Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Bianchi, C.; Rizzi, D.; Bryant, S. D.; Lazarus, L. H.
Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders
2001-01-01 Baraldi, P. G.; Balboni, Gianfranco; Pavani, M. G.; Spalluto, G.; Tabrizi, M. A.; Clercq, Ed; Balzarini, J.; Bando, T.; Sugiyama, H.; Romagnoli, R.
Inhibition of multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist
2001-01-01 Lovekamp, T; Cooper, Ps; Hardison, J; Bryant, Sd; Guerrini, R; Balboni, Gianfranco; Salvadori, S; Lazarus, Lh
Synthesis and activity of 3-pyridylamine ligands at central nicotinic receptors
2000-01-01 Balboni, Gianfranco; Marastoni, M.; Merighi, S.; Borea, P. A.; Tomatis, R.
Synthesis and binding of 3-aminopyridine derivatives at central nicotinic receptors
2000-01-01 Balboni, Gianfranco; Marastoni, M.; Merighi, S.; Borea, P. A.; Tomatis, R.
Characterization of N,N(Me)2-Dmt-Tic-OH, a delta selective opioid dipeptide antagonist
2000-01-01 Monory, K.; Bryant, S. D.; Kertesz, I.; Balboni, Gianfranco; Guerrini, R.; Toth, G.; Salvadori, S.; Lazarus, L. H.; Borsodi, A.
Effect of lysine residues on the deamidation reaction of asparagine side chains
2000-01-01 Capasso, S.; Balboni, Gianfranco; DI CERBO, P.
Assessment of substitution in the second pharmacophore of Dmt-Tic analogues
2000-01-01 Santagada, V.; Balboni, Gianfranco; Caliendo, G.; Guerrini, R.; Salvadori, S.; Bianchi, C.; Bryant, S. D.; Lazarus, L. H.
Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei
2000-01-01 Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Bianchi, C.; Santagada, V.; Caliendo, G.; Bryant, S. D.; Lazarus, L. H.
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue
2000-01-01 Labarre, M.; Butterworth, J.; ST ONGE, S.; Payza, K.; Schmidhammer, H.; Salvadori, S.; Balboni, Gianfranco; Guerrini, R.; Bryant, S. D.; Lazarus, L. H.
PNU 157977: a new potent antitumor agent exhibiting low in vivo toxicity in mice injected with L1210 leukaemia cells
1999-01-01 Baraldi, P. G.; Balboni, Gianfranco; Romagnoli, R.; Spalluto, G.; Cozzi, P.; Geroni, C.; Mongelli, N.; Rutigliano, C.; Bianchi, N.; Gambari, R.
FURTHER STUDIES ON THE DMT-TIC PHARMACOPHORE: HYDROPHOBIC SUBSTITUENTS AT THE C-TERMINUS ENDOW DELTA ANTAGONISTS TO MANIFEST MU AGONISM OR MU ANTAGONISM
1999-01-01 Salvadori, S.; Guerrini, R.; Balboni, Gianfranco; Bianchi, C.; Bryant, S. D.; Cooper, P. S.; Lazarus, L. H.
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1,4]benzodiazepine and minor-groove binding oligopyrrole carriers
1999-01-01 Baraldi, P. G.; Balboni, Gianfranco; Cacciari, B.; Guiotto, A.; Manfredini, S.; Romagnoli, R.; Spalluto, G.; Thurston, D. E.; Howard, P. W.; Bianchi, N.; Rutigliano, C.; Mischiati, C.
Opioid deltorphin C analogues containing cis- or-trans-2- or 3- or 4-aminocyclohexanecarboxylic acid residues
1999-01-01 Marastoni, M.; Guerrini, R.; Balboni, Gianfranco; Salvadori, S.; Fantin, G.; Fogagnolo, M.; Lazarus, L. H.; Tomatis, R.
Design of delta-opioid peptide antagonists for emerging drug applications.
1998-01-01 Lazarus, Lh; Bryant, Sd; Cooper, Ps; Guerrini, R; Balboni, Gianfranco; Salvadori, S.
Synthesis of 2',6'-dimethyltyrosine containing tritiated delta oioid-receptor selective antagonist dipeptide ligands with extraordinary affinity
1998-01-01 Kertesz, I; Balboni, Gianfranco; Salvadori, S; Lazarus, Lh; Toth, G.
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides
1997-01-01 Tomatis, R.; Marastoni, M.; Guerrini, R.; Balboni, Gianfranco; Sorrentino, L.; Santagada, V.; Caliendo, G.; Lazarus, L. H.; Salvadori, S.
Opioid diketopiperazines: synthesis and activity of a prptotypic class of opioid antagonists
1997-01-01 Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Tomatis, R.; Bryant, S. D.; Bianchi, C.; Attila, M.; Lazarus, L. H.
Evolution of the Dmt-Tic pharmacophore: N.terminal methylated derivatives with extraordinary delta opioid antagonist activity
1997-01-01 Salvadori, S.; Balboni, Gianfranco; Guerrini, R.; Tomatis, R.; Bianchi, C.; Bryant, S. D.; Cooper, P. S.; Lazarus, L. H.
Opioid diketopiperazines: refinement of the delta opioid antagonist pharmacophore
1997-01-01 Bryant, S. D.; Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Tomatis, R.; Lazarus, L. H.
Design of mu selective opioid dipeptide antagonists
1997-01-01 Capasso, A.; Amodeo, P.; Balboni, Gianfranco; Guerrini, R.; Lazarus, L. H.; Temussi, P. A.; Salvadori, S.
Design and solution structure of a partially rigid opioid antagonist lacking the basic center models of antagonism
1997-01-01 Crescenzi, O.; Fraternali, F.; Picone, D.; Tancredi, T.; Balboni, Gianfranco; Guerrini, R.; Lazarus, L. H.; Salvadori, S.; Temussi, P. A.
Dmt-Tic-OH a highly selective and potent delta-opioid dipeptide receptor antagonist after systemic administration in the mouse
1996-01-01 Capasso, A.; Guerrini, R.; Balboni, Gianfranco; Sorrentino, R.; Temussi, P.; Lazarus, L. H.; Bryant, S. D.; Salvadori, S.
Title | Issue Date | Author(s) | Journal | Publisher |
---|---|---|---|---|
Inhibition of the development of morphine tolerance by a potent dual mu- / delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph | 1-Jan-2008 | Jinsmaa, Y; MARCZAK E., D; Balboni, Gianfranco; Salvadori, S; Lazarus, L. H. | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | - |
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging | 1-Jan-2008 | RYU E., K; Wu, Z; Chen, K; LAZARUS L., H; MARCZAK E., D; Sasaki, Y; Ambo, A; Salvadori, S; Ren, C; Zhao, H; Balboni, Gianfranco; Chen, X. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic | 1-Jan-2008 | Balboni, Gianfranco; Fiorini, S; Baldisserotto, A; Trapella, C; Sasaki, Y; Ambo, A; MARCZAK E., D; LAZARUS L., H; Salvadori, S. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex | 1-Jan-2008 | Chao, D; BAZZY ASAAD, A; Balboni, Gianfranco; Salvadori, S; Xia, Y. | CEREBRAL CORTEX | - |
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502) | 1-Jan-2008 | Salvadori, S; Fiorini, S; Trapella, C; Porreca, F; Davis, P; Sasaki, Y; Ambo, A; MARCZAK E., D; LAZARUS L., H; Balboni, Gianfranco | BIOORGANIC & MEDICINAL CHEMISTRY | - |
Triazine compounds as antagonists at Bv8-prokineticin receptors | 1-Jan-2008 | Balboni, Gianfranco; Lazzari, I; Trapella, C; Negri, L; Lattanzi, R; Giannini, E; Nicotra, A; Melchiorri, P; Visentin, S; DE NUCCIO, C; Salvadori, S. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Biologically potent analogues of the Dmt-Tic pharmacophore and methods of use | 1-Jan-2007 | LAZARUS L., H; Balboni, Gianfranco; Salvadori, S. | - | - |
Delta-, but not mu-, opioid receptor stabilize K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia | 1-Jan-2007 | Chao, D; BAZZY ASAAD, A; Balboni, Gianfranco; Xia, Y. | JOURNAL OF CELLULAR PHYSIOLOGY | - |
In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist, correlation between desensitization and tolerance | 1-Jan-2007 | Aguila, B; Coulbault, L; Boulouaerd, M; Leveille, F; Davis, A; Toth, G; Borsodi, A; Balboni, Gianfranco; Salvadori, S; Jauzac, P; Allouche, S. | BRITISH JOURNAL OF PHARMACOLOGY | - |
A new opioid designed multiple ligand derived from the mu opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic | 1-Jan-2007 | Salvadori, S; Trapella, C; Fiorini, S; Negri, L; Lattanzi, R; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Balboni, Gianfranco | BIOORGANIC & MEDICINAL CHEMISTRY | - |
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore | 1-Jan-2007 | Balboni, Gianfranco; Onnis, Valentina; Congiu, Cenzo; Zotti, M; Sasaki, Y; Ambo, A; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Lazzari, I; Trapella, C; Salvadori, S. | BIOORGANIC & MEDICINAL CHEMISTRY | - |
Dimethyltyrosine, the Viagra of Opioids | 1-Jan-2006 | Lazarus, L. H.; Bryant, S. D.; Salvadori, S.; Guerrini, R.; Balboni, Gianfranco; Tsuda, Y.; Okada, Y. | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | - |
Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test amd regulate BDNF mRNA expression in rats | 1-Jan-2006 | TORREGROSSA M., M; JUTKIEWICZ E., M; MOSBERG H., I; Balboni, Gianfranco; WATSON S., J; Woods, J. H. | BRAIN RESEARCH | - |
6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in delta- and mu-Selective Opioid Peptides | 1-Jan-2006 | VAZQUEZ M., V; BLANCO J., B; Salvadori, S; Trapella, C; Argazzi, R; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Negri, L; Giannini, E; Lattanzi, R; Colucci, M; Balboni, Gianfranco | JOURNAL OF MEDICINAL CHEMISTRY | - |
Dmt-Tic-NH-CH2-Bid (UFP-502), a Potent DOP Receptor Agonist; In Vitro and in Vitro Studies | 1-Jan-2006 | Vergura, R; Valenti, E; HEBBES C., P; GAVIOLI E., C; Spagnolo, B; Mcdonald, J; LAMBERT D., G; Balboni, Gianfranco; Salvadori, S; Regoli, D; Calo', G. | PEPTIDES | - |
New Opioid Designed Multiple Ligand from Dmt-Tic and Morphinan Pharmacophores | 1-Jan-2006 | NEUMEYER J., L; Peng, X; KNAPP B., I; BIDLACK J., M; LAZARUS L., H; Salvadori, S; Trapella, C; Balboni, Gianfranco | JOURNAL OF MEDICINAL CHEMISTRY | - |
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore | 1-Jan-2006 | Balboni, Gianfranco; Onnis, Valentina; Congiu, Cenzo; Zotti, M; Sasaki, Y; Ambo, A; Bryant, Sd; Jinsmaa, Y; Lazarus, Lh; Trapella, C; Salvadori, S. | JOURNAL OF MEDICINAL CHEMISTRY | - |
New 2',6'-Dimethyl-L-Tyrosine (Dmt) Opioid Peptidomimetics Based on the Aba-Gly Scaffold. Development of Unique mu-Opioid Ligands | 1-Jan-2006 | Ballet, S; Salvadori, S; Trapella, C; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Negri, L; Giannini, E; Lattanzi, R; Tourwe', D; Balboni, Gianfranco | JOURNAL OF MEDICINAL CHEMISTRY | - |
Biologically potent analogues of the Dmt-Tic pharmacophore and methods of use | 1-Jan-2005 | LAZARUS L., H; Salvadori, S; Balboni, Gianfranco; Guerrini, R. | - | - |
From the potent and selective mu opioid receptor agonist H-Dmt-D-Arg-Phe-Lys-NH2 to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH | 1-Jan-2005 | Balboni, Gianfranco; Cocco, M. T.; Salvadori, S.; Romagnoli, R.; Sasaki, Y.; Okada, Y.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH2-Bid into delta-opioid antagonists by N1-benzimidazole alkylation | 1-Jan-2005 | Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Negri, L.; Giannini, E.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism | 1-Jan-2004 | Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Negri, L.; Giannini, E.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Synthesis of N-FmocN,N'-bis-Boc-5-,6- and 8-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid (5-GTIC, 6-GTIC and 8-GTIC) | 1-Jan-2004 | Severino, B; Santagada, V; Frecentese, F; Perissutti, E; Terracciano, S; Fiorino, F; Cirillo, D; Salvadori, S; Balboni, Gianfranco; Caliendo, G. | SYNTHESIS | - |
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic | 1-Jan-2004 | Balboni, Gianfranco; Salvadori, S.; DAL PIAZ, A.; Bortolotti, F.; Argazzi, R.; Negri, L.; Lattanzi, R.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism | 1-Jan-2003 | Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Negri, L.; Giannini, E.; Bryant, S. D.; Jinsmaa, Y; Lazarus, L. H. | BIOORGANIC & MEDICINAL CHEMISTRY | - |
POTENT DELTA-OPIOID RECEPTOR AGONISTS CONTAINING THE DMT-TIC PHARMACOPHORE | 1-Jan-2002 | Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Negri, L.; Giannini, E.; Jinsmaa, Y.; Bryant, S. D.; Lazarus, L. H. | JOURNAL OF MEDICINAL CHEMISTRY | - |
CRYSTAL STRUCTURES OF DIPEPTIDES CONTAINING THE DMT-TIC PHARMACOPHORE | 1-Jan-2002 | Bryant, S. D.; George, C.; FLIPPEN ANDERSON, J. L.; Deschamps, J. R.; Salvadori, S.; Balboni, Gianfranco; Guerrini, R.; Lazarus, L. H. | JOURNAL OF MEDICINAL CHEMISTRY | - |
EVALUATION OF THE DMT-TIC PHARMACOPHORE: CONVERSION OF A POTENT DELTA-OPIOID RECEPTOR ANTAGONIST INTO A POTENT DELTA AGONIST AND LIGANDS WITH MIXED PROPERTIES | 1-Jan-2002 | Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Bianchi, C.; Rizzi, D.; Bryant, S. D.; Lazarus, L. H. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders | 1-Jan-2001 | Baraldi, P. G.; Balboni, Gianfranco; Pavani, M. G.; Spalluto, G.; Tabrizi, M. A.; Clercq, Ed; Balzarini, J.; Bando, T.; Sugiyama, H.; Romagnoli, R. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Inhibition of multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist | 1-Jan-2001 | Lovekamp, T; Cooper, Ps; Hardison, J; Bryant, Sd; Guerrini, R; Balboni, Gianfranco; Salvadori, S; Lazarus, Lh | BRAIN RESEARCH | - |
Synthesis and activity of 3-pyridylamine ligands at central nicotinic receptors | 1-Jan-2000 | Balboni, Gianfranco; Marastoni, M.; Merighi, S.; Borea, P. A.; Tomatis, R. | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
Synthesis and binding of 3-aminopyridine derivatives at central nicotinic receptors | 1-Jan-2000 | Balboni, Gianfranco; Marastoni, M.; Merighi, S.; Borea, P. A.; Tomatis, R. | ARZNEIMITTEL-FORSCHUNG | - |
Characterization of N,N(Me)2-Dmt-Tic-OH, a delta selective opioid dipeptide antagonist | 1-Jan-2000 | Monory, K.; Bryant, S. D.; Kertesz, I.; Balboni, Gianfranco; Guerrini, R.; Toth, G.; Salvadori, S.; Lazarus, L. H.; Borsodi, A. | NEUROREPORT | - |
Effect of lysine residues on the deamidation reaction of asparagine side chains | 1-Jan-2000 | Capasso, S.; Balboni, Gianfranco; DI CERBO, P. | BIOPOLYMERS | - |
Assessment of substitution in the second pharmacophore of Dmt-Tic analogues | 1-Jan-2000 | Santagada, V.; Balboni, Gianfranco; Caliendo, G.; Guerrini, R.; Salvadori, S.; Bianchi, C.; Bryant, S. D.; Lazarus, L. H. | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei | 1-Jan-2000 | Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Bianchi, C.; Santagada, V.; Caliendo, G.; Bryant, S. D.; Lazarus, L. H. | PEPTIDES | - |
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue | 1-Jan-2000 | Labarre, M.; Butterworth, J.; ST ONGE, S.; Payza, K.; Schmidhammer, H.; Salvadori, S.; Balboni, Gianfranco; Guerrini, R.; Bryant, S. D.; Lazarus, L. H. | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
PNU 157977: a new potent antitumor agent exhibiting low in vivo toxicity in mice injected with L1210 leukaemia cells | 1-Jan-1999 | Baraldi, P. G.; Balboni, Gianfranco; Romagnoli, R.; Spalluto, G.; Cozzi, P.; Geroni, C.; Mongelli, N.; Rutigliano, C.; Bianchi, N.; Gambari, R. | ANTI-CANCER DRUG DESIGN | - |
FURTHER STUDIES ON THE DMT-TIC PHARMACOPHORE: HYDROPHOBIC SUBSTITUENTS AT THE C-TERMINUS ENDOW DELTA ANTAGONISTS TO MANIFEST MU AGONISM OR MU ANTAGONISM | 1-Jan-1999 | Salvadori, S.; Guerrini, R.; Balboni, Gianfranco; Bianchi, C.; Bryant, S. D.; Cooper, P. S.; Lazarus, L. H. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1,4]benzodiazepine and minor-groove binding oligopyrrole carriers | 1-Jan-1999 | Baraldi, P. G.; Balboni, Gianfranco; Cacciari, B.; Guiotto, A.; Manfredini, S.; Romagnoli, R.; Spalluto, G.; Thurston, D. E.; Howard, P. W.; Bianchi, N.; Rutigliano, C.; Mischiati, C. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Opioid deltorphin C analogues containing cis- or-trans-2- or 3- or 4-aminocyclohexanecarboxylic acid residues | 1-Jan-1999 | Marastoni, M.; Guerrini, R.; Balboni, Gianfranco; Salvadori, S.; Fantin, G.; Fogagnolo, M.; Lazarus, L. H.; Tomatis, R. | ARZNEIMITTEL-FORSCHUNG | - |
Design of delta-opioid peptide antagonists for emerging drug applications. | 1-Jan-1998 | Lazarus, Lh; Bryant, Sd; Cooper, Ps; Guerrini, R; Balboni, Gianfranco; Salvadori, S. | DRUG DISCOVERY TODAY | - |
Synthesis of 2',6'-dimethyltyrosine containing tritiated delta oioid-receptor selective antagonist dipeptide ligands with extraordinary affinity | 1-Jan-1998 | Kertesz, I; Balboni, Gianfranco; Salvadori, S; Lazarus, Lh; Toth, G. | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | - |
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides | 1-Jan-1997 | Tomatis, R.; Marastoni, M.; Guerrini, R.; Balboni, Gianfranco; Sorrentino, L.; Santagada, V.; Caliendo, G.; Lazarus, L. H.; Salvadori, S. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Opioid diketopiperazines: synthesis and activity of a prptotypic class of opioid antagonists | 1-Jan-1997 | Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Tomatis, R.; Bryant, S. D.; Bianchi, C.; Attila, M.; Lazarus, L. H. | BIOLOGICAL CHEMISTRY | - |
Evolution of the Dmt-Tic pharmacophore: N.terminal methylated derivatives with extraordinary delta opioid antagonist activity | 1-Jan-1997 | Salvadori, S.; Balboni, Gianfranco; Guerrini, R.; Tomatis, R.; Bianchi, C.; Bryant, S. D.; Cooper, P. S.; Lazarus, L. H. | JOURNAL OF MEDICINAL CHEMISTRY | - |
Opioid diketopiperazines: refinement of the delta opioid antagonist pharmacophore | 1-Jan-1997 | Bryant, S. D.; Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Tomatis, R.; Lazarus, L. H. | BIOLOGICAL CHEMISTRY | - |
Design of mu selective opioid dipeptide antagonists | 1-Jan-1997 | Capasso, A.; Amodeo, P.; Balboni, Gianfranco; Guerrini, R.; Lazarus, L. H.; Temussi, P. A.; Salvadori, S. | FEBS LETTERS | - |
Design and solution structure of a partially rigid opioid antagonist lacking the basic center models of antagonism | 1-Jan-1997 | Crescenzi, O.; Fraternali, F.; Picone, D.; Tancredi, T.; Balboni, Gianfranco; Guerrini, R.; Lazarus, L. H.; Salvadori, S.; Temussi, P. A. | EUROPEAN JOURNAL OF BIOCHEMISTRY | - |
Dmt-Tic-OH a highly selective and potent delta-opioid dipeptide receptor antagonist after systemic administration in the mouse | 1-Jan-1996 | Capasso, A.; Guerrini, R.; Balboni, Gianfranco; Sorrentino, R.; Temussi, P.; Lazarus, L. H.; Bryant, S. D.; Salvadori, S. | LIFE SCIENCES | - |
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