Showing results 101 to 150 of 195
Title Issue Date Author(s) Journal Publisher
Inhibition of the development of morphine tolerance by a potent dual mu- / delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph 1-Jan-2008 Jinsmaa, Y; MARCZAK E., D; Balboni, Gianfranco; Salvadori, S; Lazarus, L. H. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR -
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging 1-Jan-2008 RYU E., K; Wu, Z; Chen, K; LAZARUS L., H; MARCZAK E., D; Sasaki, Y; Ambo, A; Salvadori, S; Ren, C; Zhao, H; Balboni, Gianfranco; Chen, X. JOURNAL OF MEDICINAL CHEMISTRY -
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic 1-Jan-2008 Balboni, Gianfranco; Fiorini, S; Baldisserotto, A; Trapella, C; Sasaki, Y; Ambo, A; MARCZAK E., D; LAZARUS L., H; Salvadori, S. JOURNAL OF MEDICINAL CHEMISTRY -
Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex 1-Jan-2008 Chao, D; BAZZY ASAAD, A; Balboni, Gianfranco; Salvadori, S; Xia, Y. CEREBRAL CORTEX -
Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502) 1-Jan-2008 Salvadori, S; Fiorini, S; Trapella, C; Porreca, F; Davis, P; Sasaki, Y; Ambo, A; MARCZAK E., D; LAZARUS L., H; Balboni, Gianfranco BIOORGANIC & MEDICINAL CHEMISTRY -
Triazine compounds as antagonists at Bv8-prokineticin receptors 1-Jan-2008 Balboni, Gianfranco; Lazzari, I; Trapella, C; Negri, L; Lattanzi, R; Giannini, E; Nicotra, A; Melchiorri, P; Visentin, S; DE NUCCIO, C; Salvadori, S. JOURNAL OF MEDICINAL CHEMISTRY -
Biologically potent analogues of the Dmt-Tic pharmacophore and methods of use 1-Jan-2007 LAZARUS L., H; Balboni, Gianfranco; Salvadori, S. - -
Delta-, but not mu-, opioid receptor stabilize K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia 1-Jan-2007 Chao, D; BAZZY ASAAD, A; Balboni, Gianfranco; Xia, Y. JOURNAL OF CELLULAR PHYSIOLOGY -
In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist, correlation between desensitization and tolerance 1-Jan-2007 Aguila, B; Coulbault, L; Boulouaerd, M; Leveille, F; Davis, A; Toth, G; Borsodi, A; Balboni, Gianfranco; Salvadori, S; Jauzac, P; Allouche, S. BRITISH JOURNAL OF PHARMACOLOGY -
A new opioid designed multiple ligand derived from the mu opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic 1-Jan-2007 Salvadori, S; Trapella, C; Fiorini, S; Negri, L; Lattanzi, R; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Balboni, Gianfranco BIOORGANIC & MEDICINAL CHEMISTRY -
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore 1-Jan-2007 Balboni, Gianfranco; Onnis, Valentina; Congiu, Cenzo; Zotti, M; Sasaki, Y; Ambo, A; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Lazzari, I; Trapella, C; Salvadori, S. BIOORGANIC & MEDICINAL CHEMISTRY -
Dimethyltyrosine, the Viagra of Opioids 1-Jan-2006 Lazarus, L. H.; Bryant, S. D.; Salvadori, S.; Guerrini, R.; Balboni, Gianfranco; Tsuda, Y.; Okada, Y. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES -
Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test amd regulate BDNF mRNA expression in rats 1-Jan-2006 TORREGROSSA M., M; JUTKIEWICZ E., M; MOSBERG H., I; Balboni, Gianfranco; WATSON S., J; Woods, J. H. BRAIN RESEARCH -
6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in delta- and mu-Selective Opioid Peptides 1-Jan-2006 VAZQUEZ M., V; BLANCO J., B; Salvadori, S; Trapella, C; Argazzi, R; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Negri, L; Giannini, E; Lattanzi, R; Colucci, M; Balboni, Gianfranco JOURNAL OF MEDICINAL CHEMISTRY -
Dmt-Tic-NH-CH2-Bid (UFP-502), a Potent DOP Receptor Agonist; In Vitro and in Vitro Studies 1-Jan-2006 Vergura, R; Valenti, E; HEBBES C., P; GAVIOLI E., C; Spagnolo, B; Mcdonald, J; LAMBERT D., G; Balboni, Gianfranco; Salvadori, S; Regoli, D; Calo', G. PEPTIDES -
New Opioid Designed Multiple Ligand from Dmt-Tic and Morphinan Pharmacophores 1-Jan-2006 NEUMEYER J., L; Peng, X; KNAPP B., I; BIDLACK J., M; LAZARUS L., H; Salvadori, S; Trapella, C; Balboni, Gianfranco JOURNAL OF MEDICINAL CHEMISTRY -
Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore 1-Jan-2006 Balboni, Gianfranco; Onnis, Valentina; Congiu, Cenzo; Zotti, M; Sasaki, Y; Ambo, A; Bryant, Sd; Jinsmaa, Y; Lazarus, Lh; Trapella, C; Salvadori, S. JOURNAL OF MEDICINAL CHEMISTRY -
New 2',6'-Dimethyl-L-Tyrosine (Dmt) Opioid Peptidomimetics Based on the Aba-Gly Scaffold. Development of Unique mu-Opioid Ligands 1-Jan-2006 Ballet, S; Salvadori, S; Trapella, C; BRYANT S., D; Jinsmaa, Y; LAZARUS L., H; Negri, L; Giannini, E; Lattanzi, R; Tourwe', D; Balboni, Gianfranco JOURNAL OF MEDICINAL CHEMISTRY -
Biologically potent analogues of the Dmt-Tic pharmacophore and methods of use 1-Jan-2005 LAZARUS L., H; Salvadori, S; Balboni, Gianfranco; Guerrini, R. - -
From the potent and selective mu opioid receptor agonist H-Dmt-D-Arg-Phe-Lys-NH2 to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH 1-Jan-2005 Balboni, Gianfranco; Cocco, M. T.; Salvadori, S.; Romagnoli, R.; Sasaki, Y.; Okada, Y.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H. JOURNAL OF MEDICINAL CHEMISTRY -
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH2-Bid into delta-opioid antagonists by N1-benzimidazole alkylation 1-Jan-2005 Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Negri, L.; Giannini, E.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H. JOURNAL OF MEDICINAL CHEMISTRY -
Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism 1-Jan-2004 Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Negri, L.; Giannini, E.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H. JOURNAL OF MEDICINAL CHEMISTRY -
Synthesis of N-FmocN,N'-bis-Boc-5-,6- and 8-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid (5-GTIC, 6-GTIC and 8-GTIC) 1-Jan-2004 Severino, B; Santagada, V; Frecentese, F; Perissutti, E; Terracciano, S; Fiorino, F; Cirillo, D; Salvadori, S; Balboni, Gianfranco; Caliendo, G. SYNTHESIS -
Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic 1-Jan-2004 Balboni, Gianfranco; Salvadori, S.; DAL PIAZ, A.; Bortolotti, F.; Argazzi, R.; Negri, L.; Lattanzi, R.; Bryant, S. D.; Jinsmaa, Y.; Lazarus, L. H. JOURNAL OF MEDICINAL CHEMISTRY -
Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism 1-Jan-2003 Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Negri, L.; Giannini, E.; Bryant, S. D.; Jinsmaa, Y; Lazarus, L. H. BIOORGANIC & MEDICINAL CHEMISTRY -
POTENT DELTA-OPIOID RECEPTOR AGONISTS CONTAINING THE DMT-TIC PHARMACOPHORE 1-Jan-2002 Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Negri, L.; Giannini, E.; Jinsmaa, Y.; Bryant, S. D.; Lazarus, L. H. JOURNAL OF MEDICINAL CHEMISTRY -
CRYSTAL STRUCTURES OF DIPEPTIDES CONTAINING THE DMT-TIC PHARMACOPHORE 1-Jan-2002 Bryant, S. D.; George, C.; FLIPPEN ANDERSON, J. L.; Deschamps, J. R.; Salvadori, S.; Balboni, Gianfranco; Guerrini, R.; Lazarus, L. H. JOURNAL OF MEDICINAL CHEMISTRY -
EVALUATION OF THE DMT-TIC PHARMACOPHORE: CONVERSION OF A POTENT DELTA-OPIOID RECEPTOR ANTAGONIST INTO A POTENT DELTA AGONIST AND LIGANDS WITH MIXED PROPERTIES 1-Jan-2002 Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Bianchi, C.; Rizzi, D.; Bryant, S. D.; Lazarus, L. H. JOURNAL OF MEDICINAL CHEMISTRY -
Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders 1-Jan-2001 Baraldi, P. G.; Balboni, Gianfranco; Pavani, M. G.; Spalluto, G.; Tabrizi, M. A.; Clercq, Ed; Balzarini, J.; Bando, T.; Sugiyama, H.; Romagnoli, R. JOURNAL OF MEDICINAL CHEMISTRY -
Inhibition of multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist 1-Jan-2001 Lovekamp, T; Cooper, Ps; Hardison, J; Bryant, Sd; Guerrini, R; Balboni, Gianfranco; Salvadori, S; Lazarus, Lh BRAIN RESEARCH -
Synthesis and activity of 3-pyridylamine ligands at central nicotinic receptors 1-Jan-2000 Balboni, Gianfranco; Marastoni, M.; Merighi, S.; Borea, P. A.; Tomatis, R. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY -
Synthesis and binding of 3-aminopyridine derivatives at central nicotinic receptors 1-Jan-2000 Balboni, Gianfranco; Marastoni, M.; Merighi, S.; Borea, P. A.; Tomatis, R. ARZNEIMITTEL-FORSCHUNG -
Characterization of N,N(Me)2-Dmt-Tic-OH, a delta selective opioid dipeptide antagonist 1-Jan-2000 Monory, K.; Bryant, S. D.; Kertesz, I.; Balboni, Gianfranco; Guerrini, R.; Toth, G.; Salvadori, S.; Lazarus, L. H.; Borsodi, A. NEUROREPORT -
Effect of lysine residues on the deamidation reaction of asparagine side chains 1-Jan-2000 Capasso, S.; Balboni, Gianfranco; DI CERBO, P. BIOPOLYMERS -
Assessment of substitution in the second pharmacophore of Dmt-Tic analogues 1-Jan-2000 Santagada, V.; Balboni, Gianfranco; Caliendo, G.; Guerrini, R.; Salvadori, S.; Bianchi, C.; Bryant, S. D.; Lazarus, L. H. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS -
Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei 1-Jan-2000 Balboni, Gianfranco; Salvadori, S.; Guerrini, R.; Bianchi, C.; Santagada, V.; Caliendo, G.; Bryant, S. D.; Lazarus, L. H. PEPTIDES -
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue 1-Jan-2000 Labarre, M.; Butterworth, J.; ST ONGE, S.; Payza, K.; Schmidhammer, H.; Salvadori, S.; Balboni, Gianfranco; Guerrini, R.; Bryant, S. D.; Lazarus, L. H. EUROPEAN JOURNAL OF PHARMACOLOGY -
PNU 157977: a new potent antitumor agent exhibiting low in vivo toxicity in mice injected with L1210 leukaemia cells 1-Jan-1999 Baraldi, P. G.; Balboni, Gianfranco; Romagnoli, R.; Spalluto, G.; Cozzi, P.; Geroni, C.; Mongelli, N.; Rutigliano, C.; Bianchi, N.; Gambari, R. ANTI-CANCER DRUG DESIGN -
FURTHER STUDIES ON THE DMT-TIC PHARMACOPHORE: HYDROPHOBIC SUBSTITUENTS AT THE C-TERMINUS ENDOW DELTA ANTAGONISTS TO MANIFEST MU AGONISM OR MU ANTAGONISM 1-Jan-1999 Salvadori, S.; Guerrini, R.; Balboni, Gianfranco; Bianchi, C.; Bryant, S. D.; Cooper, P. S.; Lazarus, L. H. JOURNAL OF MEDICINAL CHEMISTRY -
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1,4]benzodiazepine and minor-groove binding oligopyrrole carriers 1-Jan-1999 Baraldi, P. G.; Balboni, Gianfranco; Cacciari, B.; Guiotto, A.; Manfredini, S.; Romagnoli, R.; Spalluto, G.; Thurston, D. E.; Howard, P. W.; Bianchi, N.; Rutigliano, C.; Mischiati, C. JOURNAL OF MEDICINAL CHEMISTRY -
Opioid deltorphin C analogues containing cis- or-trans-2- or 3- or 4-aminocyclohexanecarboxylic acid residues 1-Jan-1999 Marastoni, M.; Guerrini, R.; Balboni, Gianfranco; Salvadori, S.; Fantin, G.; Fogagnolo, M.; Lazarus, L. H.; Tomatis, R. ARZNEIMITTEL-FORSCHUNG -
Design of delta-opioid peptide antagonists for emerging drug applications. 1-Jan-1998 Lazarus, Lh; Bryant, Sd; Cooper, Ps; Guerrini, R; Balboni, Gianfranco; Salvadori, S. DRUG DISCOVERY TODAY -
Synthesis of 2',6'-dimethyltyrosine containing tritiated delta oioid-receptor selective antagonist dipeptide ligands with extraordinary affinity 1-Jan-1998 Kertesz, I; Balboni, Gianfranco; Salvadori, S; Lazarus, Lh; Toth, G. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS -
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides 1-Jan-1997 Tomatis, R.; Marastoni, M.; Guerrini, R.; Balboni, Gianfranco; Sorrentino, L.; Santagada, V.; Caliendo, G.; Lazarus, L. H.; Salvadori, S. JOURNAL OF MEDICINAL CHEMISTRY -
Opioid diketopiperazines: synthesis and activity of a prptotypic class of opioid antagonists 1-Jan-1997 Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Tomatis, R.; Bryant, S. D.; Bianchi, C.; Attila, M.; Lazarus, L. H. BIOLOGICAL CHEMISTRY -
Evolution of the Dmt-Tic pharmacophore: N.terminal methylated derivatives with extraordinary delta opioid antagonist activity 1-Jan-1997 Salvadori, S.; Balboni, Gianfranco; Guerrini, R.; Tomatis, R.; Bianchi, C.; Bryant, S. D.; Cooper, P. S.; Lazarus, L. H. JOURNAL OF MEDICINAL CHEMISTRY -
Opioid diketopiperazines: refinement of the delta opioid antagonist pharmacophore 1-Jan-1997 Bryant, S. D.; Balboni, Gianfranco; Guerrini, R.; Salvadori, S.; Tomatis, R.; Lazarus, L. H. BIOLOGICAL CHEMISTRY -
Design of mu selective opioid dipeptide antagonists 1-Jan-1997 Capasso, A.; Amodeo, P.; Balboni, Gianfranco; Guerrini, R.; Lazarus, L. H.; Temussi, P. A.; Salvadori, S. FEBS LETTERS -
Design and solution structure of a partially rigid opioid antagonist lacking the basic center models of antagonism 1-Jan-1997 Crescenzi, O.; Fraternali, F.; Picone, D.; Tancredi, T.; Balboni, Gianfranco; Guerrini, R.; Lazarus, L. H.; Salvadori, S.; Temussi, P. A. EUROPEAN JOURNAL OF BIOCHEMISTRY -
Dmt-Tic-OH a highly selective and potent delta-opioid dipeptide receptor antagonist after systemic administration in the mouse 1-Jan-1996 Capasso, A.; Guerrini, R.; Balboni, Gianfranco; Sorrentino, R.; Temussi, P.; Lazarus, L. H.; Bryant, S. D.; Salvadori, S. LIFE SCIENCES -
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