Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea
2024-01-01 Huang, Shiu-Wen; Hsu, Ming Jen; Chen, Hsiu-Chen; Meleddu, Rita; Distinto, Simona; Maccioni, Elias; Cottiglia, Filippo
2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms
2023-01-01 Sequeira, Lisa; Distinto, Simona; Meleddu, Rita; Gaspari, Marco; Angeli, Andrea; Cottiglia, Filippo; Secci, Daniela; Onali, Alessia; Sanna, Erica; Borges, Fernanda; Uriarte, Eugenio; Alcaro, Stefano; Supuran, Claudiu T.; Maccioni, Elias
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action
2023-01-01 Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E.
Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions
2021-01-01 Meleddu, Rita; Corona, Angela; Distinto, Simona; Cottiglia, Filippo; Deplano, Serenella; Sequeira, Lisa; Secci, Daniela; Onali, Alessia; Sanna, Erica; Esposito, Francesca; Cirone, Italo; Ortuso, Francesco; Alcaro, Stefano; Tramontano, Enzo; Mátyus, Péter; Maccioni, Elias
Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function
2021-01-01 Fois, Benedetta; Corona, Angela; Tramontano, Enzo; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Caboni, Pierluigi; Floris, Costantino; Cottiglia, Filippo
Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
2021-01-01 Meleddu, R.; Deplano, S.; Maccioni, E.; Ortuso, F.; Cottiglia, F.; Secci, D.; Onali, A.; Sanna, E.; Angeli, A.; Angius, R.; Alcaro, S.; Supuran, C. T.; Distinto, S.
New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII
2020-01-01 Meleddu, R.; Distinto, S.; Cottiglia, F.; Angius, R.; Caboni, P.; Angeli, A.; Melis, C.; Deplano, S.; Alcaro, S.; Ortuso, F.; Supuran, C. T.; Maccioni, E.
Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation
2020-01-01 Fois, B.; Distinto, S.; Meleddu, R.; Deplano, S.; Maccioni, E.; Floris, C.; Rosa, A.; Nieddu, M.; Caboni, P.; Sissi, C.; Angeli, A.; Supuran, C. T.; Cottiglia, F.
Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases
2019-01-01 Distinto, S.; Meleddu, R.; Ortuso, F.; Cottiglia, F.; Deplano, S.; SOUSA SEQUEIRA, ANA LISA; Melis, C.; Fois, B.; Angeli, A.; Capasso, C.; Angius, Riccardo; Alcaro, S.; Supuran, C. T.; Maccioni, E.
Ferulic Acid Esters and Withanolides: in Search of Withania somnifera GABAA Receptor Modulators
2019-01-01 Sonar, Vijay P.; Fois, Benedetta; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Cottiglia, Filippo; Acquas, ELIO MARIA GIOACCHINO; Kasture, Sanjay; Floris, Costantino; Colombo, Daniele; Sissi, Claudia; Sanna, Enrico; Talani, Giuseppe
Investigating the Anticancer Activity of Isatin/Dihydropyrazole Hybrids
2019-01-01 Meleddu, Rita; Petrikaite, Vilma; Distinto, Simona; Arridu, Antonella; Angius, Rossella; Serusi, Lorenzo; Škarnulytė, Laura; Endriulaitytė, Ugnė; Paškevičiu̅tė, Miglė; Cottiglia, Filippo; Gaspari, Marco; Taverna, Domenico; Deplano, Serenella; Fois, Benedetta; Maccioni, Elias
Targeting tumor associated carbonic anhydrase IX and XII: Highly isozyme selective coumarin and psoralen inhibitors
2018-01-01 Melis, Claudia; Distinto, Simona; Bianco, Giulia; Meleddu, Rita; Cottiglia, Filippo; Fois, Benedetta; Taverna, Domenico; Angius, Rossella; Alcaro, Stefano; Ortuso, Francesco; Gaspari, Marco; Angeli, Andrea; Del Prete, Sonia; Capasso, Clemente; Supuran, Claudiu T.; Maccioni, Elias
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides
2018-01-01 Meleddu, Rita; Distinto, Simona; Cottiglia, Filippo; Angius, Rossella; Gaspari, Marco; Taverna, Domenico; Melis, Claudia; Angeli, Andrea; Bianco, Giulia; Deplano, Serenella; Fois, Benedetta; Del Prete, Sonia; Capasso, Clemente; Alcaro, Stefano; Ortuso, Francesco; Yanez, Matilde; Supuran Claudiu, T.; Maccioni, Elias
Phenylpropenoids from Bupleurum fruticosum as Anti-Human Rhinovirus Species A Selective Capsid Binders
2017-01-01 Fois, Benedetta; Bianco, Giulia; Sonar, Vijay P.; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Melis, Claudia; Marras, Luisa; Pompei, Raffaello; Floris, Costantino; Caboni, Pierluigi; Cottiglia, Filippo
N-Acylbenzenesulfonamide dihydro-1,3,4-oxadiazole hybrids: seeking selectivity toward carbonic anhydrase isoforms
2017-01-01 Bianco, Giulia; Meleddu, Rita; Distinto, Simona; Cottiglia, Filippo; Gaspari, Marco; Melis, Claudia; Corona, Angela; Angius, Rossella; Angeli, Andrea; Taverna, Domenico; Alcaro, Stefano; Leitans, Janis; Kazaks, Andris; Tars, Kaspars; Supuran, Claudiu T.; Maccioni, Elias
Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
2017-01-01 Melis, Claudia; Meleddu, Rita; Angeli, Andrea; Distinto, Simona; Bianco, Giulia; Capasso, Clemente; Cottiglia, Filippo; Angius, Rossella; Supuran, Claudiu T.; Maccioni, Elias
Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase
2017-01-01 Sonar, VIJAY PRAKASH; Corona, Angela; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Fois, Benedetta; Floris, Costantino; Malpure, Nilesh V.; Alcaro, Stefano; Tramontano, Enzo; Cottiglia, Filippo
Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B
2017-01-01 Meleddu, Rita; Distinto, Simona; Cirilli, Roberto; Alcaro, Stefano; Yanez, Matilde; Sanna, MARIA LUISA; Corona, Angela; Melis, Claudia; Bianco, Giulia; Matyus, Peter; Cottiglia, Filippo; Maccioni, Elias
Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase
2017-01-01 Meleddu, Rita; Distinto, Simona; Corona, Angela; Tramontano, Enzo; Bianco, Giulia; Melis, Claudia; Cottiglia, Filippo; Maccioni, Elias
Ribonuclease H/DNA polymerase HIV-1 reverse transcriptase dual inhibitor: mechanistic studies on the allosteric mode of action of isatin-based compound RMNC6
2016-01-01 Corona, Angela; Meleddu, Rita; Esposito, Francesca; Distinto, Simona; Bianco, Giulia; Masaoka, T; Maccioni, Elias; Menéndez Arias, L; Alcaro, S; Le Grice, Sfj; Tramontano, Enzo
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold
2016-01-01 Distinto, Simona; Meleddu, Rita; Yanez, Matilde; Cirilli, Roberto; Bianco, Giulia; Sanna, MARIA LUISA; Arridu, Antonella; Cossu, Pietro; Cottiglia, Filippo; Faggi, Cristina; Ortuso, Francesco; Alcaro, Stefano; Maccioni, Elias
Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida
2016-01-01 Meleddu, Rita; Distinto, Simona; Corona, Angela; Maccioni, Elias; Arridu, Antonella; Melis, Claudia; Bianco, Giulia; Matyus, Peter; Cottiglia, Filippo; Sanna, Adriana; DE LOGU, Alessandro
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase
2015-01-01 Meleddu, Rita; Distinto, Simona; Corona, Angela; Bianco, Giulia; Cannas, Valeria; Esposito, Francesca; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, Filippo; Tramontano, Enzo; Maccioni, Elias
Systemic lupus erythematosus occurring in a patient with Niemann-Pick type B disease.
2015-01-01 Murgia, Giuseppe; Firinu, Davide; Meleddu, Rita; Lorrai, MARIA MADDALENA; Manconi, PAOLO EMILIO; DEL GIACCO, Stefano
New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII
2015-01-01 Meleddu, Rita; Maccioni, Elias; Distinto, Simona; Bianco, Giulia; Melis, Claudia; Alcaro, Stefano; Cottiglia, Filippo; Ceruso, Mariangela; Supuran, Claudiu T.
2-methoxynaphthalen thiazole derivate : a new HIV-1 RT Ribonuclease H/DNA polymerase dual inhibitor active on viral replication
2014-01-01 Corona, Angela; Meleddu, R.; Esposito, E.; Distinto, S.; Bianco, G.; Maccioni, E.; Tramontano, E. .
Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) enlighten the mechanism of action of a new Ribonuclease H/DNA polymerase RT dual inhibitor
2014-01-01 Esposito, Francesca; Corona, Angela; Meleddu, Rita; Distinto, Simona; Giulia, Bianco; Maccioni, Elias; Stuart JF Le Grice, ; Enzo, Tramontano
Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase
2014-01-01 Meleddu, Rita; Cannas, Valeria; Distinto, Simona; Sarais, Giorgia; Del Vecchio, C; Esposito, Francesca; Bianco, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Artese, A; Scalise, D; Fresta, M; Arridu, A; Ortuso, F; Maccioni, Elias; Tramontano, Enzo
Synthesis of different series of small molecules targeting HIV-1 RT, Candida albicans, MAO and G-Quadruplex
2013-04-11
2-(2-cycloalkylidene hydrazin-1-yl)-4-aryl-1,3-thiazoles: a promising class of antifungal agents
2013-01-01 Arridu, A.; Meleddu, R.; Bianco, Giulia; Distinto, Simona; DE LOGU, Alessandro; Matyus, P.; Maccioni, Elias
Synthesis and biological activity evaluation of new dual-inhibitors of both associated functions of HIV-1 RT
2013-01-01 Meleddu, R.; Distinto, Simona; Corona, Angela; Bianco, Giulia; Arridu, A.; Cannas, V.; Tramontano, Enzo; Alcaro, S.; Matyus, P.; Maccioni, Elias
Design, Synthesis and Biological Evaluation of New 1,3-Diarylpropenones as Dual Inhibitors of HIV-1 RT.
2013-01-01 Esposito, Francesca; Meleddu, R; Cannas, V; Distinto, Simona; Del Vecchio, C; Biano, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Maccioni, Elias; Tramontano, Enzo
Design, Synthesis and Biological Evaluation of New 1,3-Diarylpropenones as Single Site Dual Inhibitors of HIV-1 RT
2013-01-01 Esposito, Francesca; Meleddu, R; Cannas, Valeria; Distinto, Simona; Del Vecchio, C; Bianco, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Maccioni, Elias; Tramontano, Enzo
A novel series of 3,4-disubstituted dihydropyrazoles: Synthesis and evaluation for MAO enzyme inhibition
2013-01-01 Cardia, MARIA CRISTINA; Sanna, MARIA LUISA; Meleddu, Rita; Distinto, Simona; Yañez, M.; Viña, D.; Lamela, M.; Maccioni, Elias
Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor
2013-01-01 Corona, Angela; Meleddu, Rita; Esposito, Francesca; Distinto, Simona; Bianco, Giulia; Maccioni, Elias; Le Grice, S.; Tramontano, Enzo
Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors
2013-01-01 Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Corona, Angela; Alcaro, S; Tramontano, Enzo
Synthesis and biological evaluation of new dual inhibitors of HIV-1 associated functions
2012-01-01 Tramontano, Enzo; Meleddu, R.; Corona, Angela; Distinto, Simona; Esposito, Francesca; Cannas, V.; Alcaro, S.; Costa, G.; Ortuso, F.; Maccioni, Elias
SITE DIRECT MUTAGENESIS AND KINETIC STUDIES TO EXPLORE THE MECHANISM OF ACTION OF ISATIN DERIVATIVES AS HIV-1 REVERSE TRANSCRIPTASE DUAL INHIBITORS
2012-01-01 Corona, Angela; Meleddu, R.; Esposito, Francesca; Distinto, S.; Maccioni, Elias; Tramontano, S. Le Griceand E.
From classic to innovative approaches in HIV-1 infection treatment
2012-01-01 Maccioni, Elias; Distinto, Simona; Alcaro, S.; Meleddu, R.; Esposito, Francesca; Corona, Angela; Sanna, M. L.; Tramontano, Enzo
Mutagenic study on HIV-1 reverse transcriptase to explore the mechanism of action of HIV-1 reverse transcriptase dual inhibitors
2012-01-01 Corona, Angela; Meleddu, R.; Esposito, Francesca; Sanna, M. L.; Distinto, Simona; Maccioni, Elias; Tramontano, Enzo
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B
2012-01-01 Distinto, Simona; Yáñez, M; Alcaro, S; Cardia, MARIA CRISTINA; Gaspari, M; Sanna, MARIA LUISA; Meleddu, Rita; Ortuso, F; Kirchmair, J; Markt, P; Bolasco, A; Wolber, G; Secci, D; Maccioni, Elias
New promising scaffolds for the inhibition of monoamine oxidase B
2011-01-01 Sanna, M. L.; Meleddu, Rita; Cardia, M. C.; Distinto, Simona; Alcaro, S.; Maccioni, Elias
Design, synthesis and biological activity evaluation of new HIV-1 reverse transcriptase dual inhibitors
2011-01-01 Meleddu, R.; Corona, Angela; Distinto, Simona; Sanna, M. L.; Esposito, Francesca; Cardia, M. C.; Tramontano, Enzo; Maccioni, Elias
Exploring new scaffolds for the inhibition of the Ribonuclease H function of RT HIV-1
2011-01-01 Meleddu, R.; Corona, Angela; Distinto, Simona; Esposito, Francesca; Sanna, M. L.; Cardia, C.; Tramontano, Enzo; Maccioni, Elias
Exploring new scaffolds for the inibition of the Ribonuclease H function of RT HIV-1
2011-01-01 Meleddu, Rita; Corona, Angela; Distinto, S; Esposito, Francesca; Sanna M., L; Cardia M., C; Tramontano, Enzo; Maccioni, Elias
Design, synthesis and biolgical activity evaluation of new HIV-1 reverse transcriptase dual inhibitors
2011-01-01 Meleddu, Rita; Corona, Angela; Sanna M., L; Esposito, Francesca; Cardia M., C; Tramontano, Enzo; Maccioni, Elias
Isatin derivatives as new scaffolds for HIV-1 reverse transcriptase associated RNase H and RDDP dual inhibitors
2011-01-01 Corona, Angela; Meleddu, Rita; Esposito, Francesca; Sanna, M. L.; Distinto, Simona; Maccioni, Elias; Tramontano, Enzo
Chalcones as novel dual inhibitors of HIV-1 reverse transcriptase
2011-01-01 Meleddu, Rita; Corona, Angela; Esposito, Francesca; Tramontano, Enzo; Distinto, Simona; Sanna, M. L.; Cardia, C.; Alcaro, S.; Maccioni, Elias
3-[2-(4-aryl-1,3-thiazol-2-yl)hydrazin-1-ylidene]-1H-indol-2-ones as new potential dual inhibitors of polimerase and ribonuclease HIV-1 RT associated function
2011-01-01 Meleddu, Rita; Corona, Angela; Distinto, Simona; Esposito, Francesca; Sanna, M. L.; Cardia, C.; Tramontano, Enzo; Maccioni, Elias
Design and synthesis of new Isatin derivatives as HIV-1 Reverse Transcriptase associated Ribonuclease H inhibitors twenty-fourth
2011-01-01 Esposito, Francesca; Meleddu, Rita; Sanna M., L; Distinto, S; Corona, Angela; Cannas, V; Tramontano, Enzo; Cardia, M. C.
Title | Issue Date | Author(s) | Journal | Publisher |
---|---|---|---|---|
Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea | 1-Jan-2024 | Huang, Shiu-Wen; Hsu, Ming Jen; Chen, Hsiu-Chen; Meleddu, Rita; Distinto, Simona; Maccioni, Elias; Cottiglia, Filippo | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms | 1-Jan-2023 | Sequeira, Lisa; Distinto, Simona; Meleddu, Rita; Gaspari, Marco; Angeli, Andrea; Cottiglia, Filippo; Secci, Daniela; Onali, Alessia; Sanna, Erica; Borges, Fernanda; Uriarte, Eugenio; Alcaro, Stefano; Supuran, Claudiu T.; Maccioni, Elias | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action | 1-Jan-2023 | Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E. | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | - |
Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions | 1-Jan-2021 | Meleddu, Rita; Corona, Angela; Distinto, Simona; Cottiglia, Filippo; Deplano, Serenella; Sequeira, Lisa; Secci, Daniela; Onali, Alessia; Sanna, Erica; Esposito, Francesca; Cirone, Italo; Ortuso, Francesco; Alcaro, Stefano; Tramontano, Enzo; Mátyus, Péter; Maccioni, Elias | MOLECULES | - |
Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function | 1-Jan-2021 | Fois, Benedetta; Corona, Angela; Tramontano, Enzo; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Caboni, Pierluigi; Floris, Costantino; Cottiglia, Filippo | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives | 1-Jan-2021 | Meleddu, R.; Deplano, S.; Maccioni, E.; Ortuso, F.; Cottiglia, F.; Secci, D.; Onali, A.; Sanna, E.; Angeli, A.; Angius, R.; Alcaro, S.; Supuran, C. T.; Distinto, S. | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII | 1-Jan-2020 | Meleddu, R.; Distinto, S.; Cottiglia, F.; Angius, R.; Caboni, P.; Angeli, A.; Melis, C.; Deplano, S.; Alcaro, S.; Ortuso, F.; Supuran, C. T.; Maccioni, E. | ACS MEDICINAL CHEMISTRY LETTERS | - |
Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation | 1-Jan-2020 | Fois, B.; Distinto, S.; Meleddu, R.; Deplano, S.; Maccioni, E.; Floris, C.; Rosa, A.; Nieddu, M.; Caboni, P.; Sissi, C.; Angeli, A.; Supuran, C. T.; Cottiglia, F. | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases | 1-Jan-2019 | Distinto, S.; Meleddu, R.; Ortuso, F.; Cottiglia, F.; Deplano, S.; SOUSA SEQUEIRA, ANA LISA; Melis, C.; Fois, B.; Angeli, A.; Capasso, C.; Angius, Riccardo; Alcaro, S.; Supuran, C. T.; Maccioni, E. | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
Ferulic Acid Esters and Withanolides: in Search of Withania somnifera GABAA Receptor Modulators | 1-Jan-2019 | Sonar, Vijay P.; Fois, Benedetta; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Cottiglia, Filippo; Acquas, ELIO MARIA GIOACCHINO; Kasture, Sanjay; Floris, Costantino; Colombo, Daniele; Sissi, Claudia; Sanna, Enrico; Talani, Giuseppe | JOURNAL OF NATURAL PRODUCTS | - |
Investigating the Anticancer Activity of Isatin/Dihydropyrazole Hybrids | 1-Jan-2019 | Meleddu, Rita; Petrikaite, Vilma; Distinto, Simona; Arridu, Antonella; Angius, Rossella; Serusi, Lorenzo; Škarnulytė, Laura; Endriulaitytė, Ugnė; Paškevičiu̅tė, Miglė; Cottiglia, Filippo; Gaspari, Marco; Taverna, Domenico; Deplano, Serenella; Fois, Benedetta; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
Targeting tumor associated carbonic anhydrase IX and XII: Highly isozyme selective coumarin and psoralen inhibitors | 1-Jan-2018 | Melis, Claudia; Distinto, Simona; Bianco, Giulia; Meleddu, Rita; Cottiglia, Filippo; Fois, Benedetta; Taverna, Domenico; Angius, Rossella; Alcaro, Stefano; Ortuso, Francesco; Gaspari, Marco; Angeli, Andrea; Del Prete, Sonia; Capasso, Clemente; Supuran, Claudiu T.; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides | 1-Jan-2018 | Meleddu, Rita; Distinto, Simona; Cottiglia, Filippo; Angius, Rossella; Gaspari, Marco; Taverna, Domenico; Melis, Claudia; Angeli, Andrea; Bianco, Giulia; Deplano, Serenella; Fois, Benedetta; Del Prete, Sonia; Capasso, Clemente; Alcaro, Stefano; Ortuso, Francesco; Yanez, Matilde; Supuran Claudiu, T.; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
Phenylpropenoids from Bupleurum fruticosum as Anti-Human Rhinovirus Species A Selective Capsid Binders | 1-Jan-2017 | Fois, Benedetta; Bianco, Giulia; Sonar, Vijay P.; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Melis, Claudia; Marras, Luisa; Pompei, Raffaello; Floris, Costantino; Caboni, Pierluigi; Cottiglia, Filippo | JOURNAL OF NATURAL PRODUCTS | - |
N-Acylbenzenesulfonamide dihydro-1,3,4-oxadiazole hybrids: seeking selectivity toward carbonic anhydrase isoforms | 1-Jan-2017 | Bianco, Giulia; Meleddu, Rita; Distinto, Simona; Cottiglia, Filippo; Gaspari, Marco; Melis, Claudia; Corona, Angela; Angius, Rossella; Angeli, Andrea; Taverna, Domenico; Alcaro, Stefano; Leitans, Janis; Kazaks, Andris; Tars, Kaspars; Supuran, Claudiu T.; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors | 1-Jan-2017 | Melis, Claudia; Meleddu, Rita; Angeli, Andrea; Distinto, Simona; Bianco, Giulia; Capasso, Clemente; Cottiglia, Filippo; Angius, Rossella; Supuran, Claudiu T.; Maccioni, Elias | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase | 1-Jan-2017 | Sonar, VIJAY PRAKASH; Corona, Angela; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Fois, Benedetta; Floris, Costantino; Malpure, Nilesh V.; Alcaro, Stefano; Tramontano, Enzo; Cottiglia, Filippo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B | 1-Jan-2017 | Meleddu, Rita; Distinto, Simona; Cirilli, Roberto; Alcaro, Stefano; Yanez, Matilde; Sanna, MARIA LUISA; Corona, Angela; Melis, Claudia; Bianco, Giulia; Matyus, Peter; Cottiglia, Filippo; Maccioni, Elias | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase | 1-Jan-2017 | Meleddu, Rita; Distinto, Simona; Corona, Angela; Tramontano, Enzo; Bianco, Giulia; Melis, Claudia; Cottiglia, Filippo; Maccioni, Elias | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
Ribonuclease H/DNA polymerase HIV-1 reverse transcriptase dual inhibitor: mechanistic studies on the allosteric mode of action of isatin-based compound RMNC6 | 1-Jan-2016 | Corona, Angela; Meleddu, Rita; Esposito, Francesca; Distinto, Simona; Bianco, Giulia; Masaoka, T; Maccioni, Elias; Menéndez Arias, L; Alcaro, S; Le Grice, Sfj; Tramontano, Enzo | PLOS ONE | - |
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold | 1-Jan-2016 | Distinto, Simona; Meleddu, Rita; Yanez, Matilde; Cirilli, Roberto; Bianco, Giulia; Sanna, MARIA LUISA; Arridu, Antonella; Cossu, Pietro; Cottiglia, Filippo; Faggi, Cristina; Ortuso, Francesco; Alcaro, Stefano; Maccioni, Elias | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida | 1-Jan-2016 | Meleddu, Rita; Distinto, Simona; Corona, Angela; Maccioni, Elias; Arridu, Antonella; Melis, Claudia; Bianco, Giulia; Matyus, Peter; Cottiglia, Filippo; Sanna, Adriana; DE LOGU, Alessandro | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase | 1-Jan-2015 | Meleddu, Rita; Distinto, Simona; Corona, Angela; Bianco, Giulia; Cannas, Valeria; Esposito, Francesca; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, Filippo; Tramontano, Enzo; Maccioni, Elias | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
Systemic lupus erythematosus occurring in a patient with Niemann-Pick type B disease. | 1-Jan-2015 | Murgia, Giuseppe; Firinu, Davide; Meleddu, Rita; Lorrai, MARIA MADDALENA; Manconi, PAOLO EMILIO; DEL GIACCO, Stefano | LUPUS | - |
New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII | 1-Jan-2015 | Meleddu, Rita; Maccioni, Elias; Distinto, Simona; Bianco, Giulia; Melis, Claudia; Alcaro, Stefano; Cottiglia, Filippo; Ceruso, Mariangela; Supuran, Claudiu T. | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
2-methoxynaphthalen thiazole derivate : a new HIV-1 RT Ribonuclease H/DNA polymerase dual inhibitor active on viral replication | 1-Jan-2014 | Corona, Angela; Meleddu, R.; Esposito, E.; Distinto, S.; Bianco, G.; Maccioni, E.; Tramontano, E. . | - | - |
Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) enlighten the mechanism of action of a new Ribonuclease H/DNA polymerase RT dual inhibitor | 1-Jan-2014 | Esposito, Francesca; Corona, Angela; Meleddu, Rita; Distinto, Simona; Giulia, Bianco; Maccioni, Elias; Stuart JF Le Grice, ; Enzo, Tramontano | - | - |
Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase | 1-Jan-2014 | Meleddu, Rita; Cannas, Valeria; Distinto, Simona; Sarais, Giorgia; Del Vecchio, C; Esposito, Francesca; Bianco, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Artese, A; Scalise, D; Fresta, M; Arridu, A; Ortuso, F; Maccioni, Elias; Tramontano, Enzo | CHEMMEDCHEM | - |
Synthesis of different series of small molecules targeting HIV-1 RT, Candida albicans, MAO and G-Quadruplex | 11-Apr-2013 | - | - | Università degli Studi di Cagliari |
2-(2-cycloalkylidene hydrazin-1-yl)-4-aryl-1,3-thiazoles: a promising class of antifungal agents | 1-Jan-2013 | Arridu, A.; Meleddu, R.; Bianco, Giulia; Distinto, Simona; DE LOGU, Alessandro; Matyus, P.; Maccioni, Elias | - | - |
Synthesis and biological activity evaluation of new dual-inhibitors of both associated functions of HIV-1 RT | 1-Jan-2013 | Meleddu, R.; Distinto, Simona; Corona, Angela; Bianco, Giulia; Arridu, A.; Cannas, V.; Tramontano, Enzo; Alcaro, S.; Matyus, P.; Maccioni, Elias | - | - |
Design, Synthesis and Biological Evaluation of New 1,3-Diarylpropenones as Dual Inhibitors of HIV-1 RT. | 1-Jan-2013 | Esposito, Francesca; Meleddu, R; Cannas, V; Distinto, Simona; Del Vecchio, C; Biano, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Maccioni, Elias; Tramontano, Enzo | - | - |
Design, Synthesis and Biological Evaluation of New 1,3-Diarylpropenones as Single Site Dual Inhibitors of HIV-1 RT | 1-Jan-2013 | Esposito, Francesca; Meleddu, R; Cannas, Valeria; Distinto, Simona; Del Vecchio, C; Bianco, G; Corona, Angela; Cottiglia, Filippo; Alcaro, S; Parolin, C; Maccioni, Elias; Tramontano, Enzo | VIROLOGIE | - |
A novel series of 3,4-disubstituted dihydropyrazoles: Synthesis and evaluation for MAO enzyme inhibition | 1-Jan-2013 | Cardia, MARIA CRISTINA; Sanna, MARIA LUISA; Meleddu, Rita; Distinto, Simona; Yañez, M.; Viña, D.; Lamela, M.; Maccioni, Elias | JOURNAL OF HETEROCYCLIC CHEMISTRY | - |
Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor | 1-Jan-2013 | Corona, Angela; Meleddu, Rita; Esposito, Francesca; Distinto, Simona; Bianco, Giulia; Maccioni, Elias; Le Grice, S.; Tramontano, Enzo | RETROVIROLOGY | BioMed Central Ltd |
Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors | 1-Jan-2013 | Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Corona, Angela; Alcaro, S; Tramontano, Enzo | CURRENT PHARMACEUTICAL DESIGN | - |
Synthesis and biological evaluation of new dual inhibitors of HIV-1 associated functions | 1-Jan-2012 | Tramontano, Enzo; Meleddu, R.; Corona, Angela; Distinto, Simona; Esposito, Francesca; Cannas, V.; Alcaro, S.; Costa, G.; Ortuso, F.; Maccioni, Elias | - | - |
SITE DIRECT MUTAGENESIS AND KINETIC STUDIES TO EXPLORE THE MECHANISM OF ACTION OF ISATIN DERIVATIVES AS HIV-1 REVERSE TRANSCRIPTASE DUAL INHIBITORS | 1-Jan-2012 | Corona, Angela; Meleddu, R.; Esposito, Francesca; Distinto, S.; Maccioni, Elias; Tramontano, S. Le Griceand E. | - | - |
From classic to innovative approaches in HIV-1 infection treatment | 1-Jan-2012 | Maccioni, Elias; Distinto, Simona; Alcaro, S.; Meleddu, R.; Esposito, Francesca; Corona, Angela; Sanna, M. L.; Tramontano, Enzo | - | - |
Mutagenic study on HIV-1 reverse transcriptase to explore the mechanism of action of HIV-1 reverse transcriptase dual inhibitors | 1-Jan-2012 | Corona, Angela; Meleddu, R.; Esposito, Francesca; Sanna, M. L.; Distinto, Simona; Maccioni, Elias; Tramontano, Enzo | - | - |
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B | 1-Jan-2012 | Distinto, Simona; Yáñez, M; Alcaro, S; Cardia, MARIA CRISTINA; Gaspari, M; Sanna, MARIA LUISA; Meleddu, Rita; Ortuso, F; Kirchmair, J; Markt, P; Bolasco, A; Wolber, G; Secci, D; Maccioni, Elias | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
New promising scaffolds for the inhibition of monoamine oxidase B | 1-Jan-2011 | Sanna, M. L.; Meleddu, Rita; Cardia, M. C.; Distinto, Simona; Alcaro, S.; Maccioni, Elias | - | - |
Design, synthesis and biological activity evaluation of new HIV-1 reverse transcriptase dual inhibitors | 1-Jan-2011 | Meleddu, R.; Corona, Angela; Distinto, Simona; Sanna, M. L.; Esposito, Francesca; Cardia, M. C.; Tramontano, Enzo; Maccioni, Elias | - | - |
Exploring new scaffolds for the inhibition of the Ribonuclease H function of RT HIV-1 | 1-Jan-2011 | Meleddu, R.; Corona, Angela; Distinto, Simona; Esposito, Francesca; Sanna, M. L.; Cardia, C.; Tramontano, Enzo; Maccioni, Elias | - | - |
Exploring new scaffolds for the inibition of the Ribonuclease H function of RT HIV-1 | 1-Jan-2011 | Meleddu, Rita; Corona, Angela; Distinto, S; Esposito, Francesca; Sanna M., L; Cardia M., C; Tramontano, Enzo; Maccioni, Elias | - | - |
Design, synthesis and biolgical activity evaluation of new HIV-1 reverse transcriptase dual inhibitors | 1-Jan-2011 | Meleddu, Rita; Corona, Angela; Sanna M., L; Esposito, Francesca; Cardia M., C; Tramontano, Enzo; Maccioni, Elias | - | - |
Isatin derivatives as new scaffolds for HIV-1 reverse transcriptase associated RNase H and RDDP dual inhibitors | 1-Jan-2011 | Corona, Angela; Meleddu, Rita; Esposito, Francesca; Sanna, M. L.; Distinto, Simona; Maccioni, Elias; Tramontano, Enzo | - | - |
Chalcones as novel dual inhibitors of HIV-1 reverse transcriptase | 1-Jan-2011 | Meleddu, Rita; Corona, Angela; Esposito, Francesca; Tramontano, Enzo; Distinto, Simona; Sanna, M. L.; Cardia, C.; Alcaro, S.; Maccioni, Elias | - | - |
3-[2-(4-aryl-1,3-thiazol-2-yl)hydrazin-1-ylidene]-1H-indol-2-ones as new potential dual inhibitors of polimerase and ribonuclease HIV-1 RT associated function | 1-Jan-2011 | Meleddu, Rita; Corona, Angela; Distinto, Simona; Esposito, Francesca; Sanna, M. L.; Cardia, C.; Tramontano, Enzo; Maccioni, Elias | - | - |
Design and synthesis of new Isatin derivatives as HIV-1 Reverse Transcriptase associated Ribonuclease H inhibitors twenty-fourth | 1-Jan-2011 | Esposito, Francesca; Meleddu, Rita; Sanna M., L; Distinto, S; Corona, Angela; Cannas, V; Tramontano, Enzo; Cardia, M. C. | - | - |
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