PhD Programme in Life, Environmental and Drug Sciences

The PhD programme involves a multidisciplinary team of professors with expertise across the fields of biology and chemistry. Their research covers several key areas: biochemistry, genetics, and microbiology for research in biomedical sciences; zoology, biological anthropology, and ecology for environmental biology (including marine, animal, and human systems) and organic chemistry, pharmacology, pharmaceutical sciences, and pharmaceutical technologies for research focused on drug development.

The PhD course is organized into three curricula:

  • Biomedical, in which students focus on research activities in the fields of biochemistry, genetics and microbiology;
  • Human and Animal Biology and Ecology, in which students focus on research activities in the fields of anthropology, ecology and zoology;
  • Drug Sciences, in which students focus on research activities in the fields of medicinal chemistry, nutraceuticals, pharmacology, organic chemistry and pharmaceutical technology.

Educational Objectives

The PhD in Life, Environmental and Drug Sciences is a three-year doctoral programme designed to train scientists capable of conducting independent, original, and high-level research across biology, environmental sciences, and pharmaceutical sciences.

The programme aims to provide doctoral candidates with a solid foundation in advanced methodologies, interdisciplinary approaches, international collaboration, and transferable skills essential for careers in academia, industry, or public institutions.

Educational objectives are structured over three years, with progressive acquisition of scientific, technical, and professional competencies. The training path is personalized based on each student's curriculum and research project while maintaining common goals and standards across all curricula.

First Year Objectives

During the first year, students of all curricula (Biomedical Sciences,  Human/Animal Biology and Ecology, Drug Sciences) are expected to:

  • Possess a systematic understanding of a research theme within their specific field.
  • Acquire and apply scientific methodologies, tools, and statistical techniques for the analysis of biological, environmental, or pharmaceutical processes and challenges.
  • Approach scientific problems critically, formulating research questions that are relevant and innovative.
  • Develop and apply experimental approaches, demonstrating the ability to design, plan, and execute research strategies independently.
  • Receive targeted technical training in laboratory practices, instrumentation, safety (e.g., GLP, BSL3, animal experimentation), and ethics in research.
  • Present a Project Proposal.
  • Participate in mandatory courses and seminars to strengthen their scientific background and cross-disciplinary knowledge.

 

Second Year Objectives

In the second year, students will:

  • Analyse and interpret research data and use these results to formulate new hypotheses and design subsequent experiments.
  • Present the results to the Scientific Group and then to the PhD Board and colleagues.
  • Enhance problem-solving abilities, adapting methodologies and strategies as research evolves.
  • Acquire knowledge of research management, including national/international project design, intellectual property rights, and research valorisation.
  • Initiate the dissemination of research results through conference presentations and academic events, supported financially by the Supervisor, and begin drafting scientific manuscripts for publication.
  • Undertake international research stay (minimum 6 months) to raise collaboration and broaden scientific perspectives.
  • Participate in knowledge transfer and public engagement (Third Mission), through outreach activities, workshops, and communication events.

 

Third Year Objectives

In the final year, students will:

  • Complete their international research experience, integrating new skills and collaborations into their project.
  • Develop strong communication skills, particularly in preparing and delivering conference presentations and writing scientific articles in English.
  • Critically evaluate their research, identifying strengths, limitations, and future directions.
  • Present the results to the Scientific Group and then to the PhD Board and colleagues.
  • Finalize and defend their doctoral thesis, demonstrating scientific maturity and autonomy.
  • Contribute to knowledge transfer and public engagement (Third Mission), through outreach activities, workshops, and communication events.

 

Integrated Competencies Across the PhD Path

Throughout the PhD programme, students will:

  • Gain interdisciplinary and multidisciplinary competencies, adapting to evolving research landscapes.
  • Achieve a certified C1 level in English, essential for scientific communication and international collaboration.
  • Participate in transferable skills training, including research ethics, data management, grant writing, teaching and mentoring, and career development.
  • Customize their training plan in agreement with their Supervisor, balancing mandatory and optional activities to meet the 180 FC (Formative Credit) requirement.
  • Participate actively in the academic community, through research seminars, annual reports, thesis presentations, and internal evaluations.
  • By the end of the programme, PhD graduates will be fully equipped to pursue careers as independent researchers, contributing to scientific advancement and addressing societal challenges at the national and international level.

Research Topics

Our PhD course is structured into three curricula.

Biomedical curriculum

The Curriculum provides a solid knowledge on complex biological systems focused on structural and functional biochemistry of proteins and nucleic acids, integrating notions focused on protein/ligand interactions (i.e. salivary proteins, or interaction viral proteins/small molecules), protein/protein interactions (i.e. viral vs cellular proteins interactions), proteins/nucleic acid interactions (i.e. for proteins involved in autoimmune diseases, RNA for proteins involved in innate immune system down-regulation).

More specifically, the investigational areas for this curriculum are:

  • study of the proteome of biological fluids, human cells or tissues, using top-down and bottom-up proteomic approaches in order to obtain protein profiles useful for the identification of possible biomarkers for the diagnosis of different pathologies;
  • characterization of the acid-insoluble fraction of the proteome of biological fluids, cells, and tissues by two-dimensional electrophoresis to highlight protein biomarkers of specific diseases;
  • study of single nucleotide polymorphisms (SNPs) in genes coding for proteins present in biological fluids;
  • analysis of human genomic sequences of retroviral origin involved with autoimmune diseases widespread in Sardinia;
  • identification and functional characterization of regulatory proteins involved in the pathogenesis of autoimmune diseases;
  • identification and characterization of new viral targets for therapeutic purposes using biological and computational techniques and identification of new antiviral drugs;
  • evaluation of the inhibitory activity of newly synthesized compounds against tyrosinase and search for bioactive substances in plant extracts.
Animal and Human Biology, and Ecology curriculum

The Curriculum provides a solid knowledge regarding the valorisation of marine biodiversity with reference to fish and macro-invertebrate species that characterize the sea and inland waters of Sardinia, through theoretical and experimental studies that enhance the quality and safety of food products, with particular regard to the promotion and protection of typical products of the island (eg. bottarga, lobster, sea urchin pulp, shrimp, tuna, octopus).

More specifically, the learning objectives for the first year include:

The study of the natural environment in all its biotic and abiotic components for the analysis of processes, systems and productive problems with special attention to the marine and brackish ecosystems (sea and lagoons).

The study of conservation and sustainable use of marine biodiversity in the Mediterranean. In particular, the following main topics will be addressed: reproductive cycles, estimates of abundance, distribution, recruitment mechanisms and bio-ecological correlations for Mediterranean teleosts, crustaceans, cephalopods and selachian species.

The curriculum itself provides skills related to the ability to:

  1. plan interventions for the prevention, management, protection, and conservation of natural resources;
  2. assess the impact of anthropisation;
  3. design programs of environment restoration.

In addition, the Curriculum provides a solid knowledge concerning the definition of micro-evolutionary processes of human populations, in the light of molecular, anthropometric, biodemographic, and osteological data, and those arising from the ‘man-environment’ interactions.

More specifically, the learning objectives include:

  • the systematics analysis of fossil remains of the human lineage and of bioarchaeological field in its osteological, paleo-demographic and molecular aspects;
  • study of the evolution of cultures and subsistence strategies in their naturalistic aspects;
  • reconstruction of the history of human settlement through the study of bio-anthropological and molecular markers;
  • study of single-parent molecular markers for the identification of marriage and cultural behaviours and of migration patterns;
  • study of the different susceptibility to diseases in human populations; evaluation of anthropometric characteristics and body composition in relation to the life cycle and motor activities.
Drug Sciences Curriculum

The Curriculum aims at providing a sound knowledge to train qualified experts in the pharmaceutical field.

In particular, issues will be addressed concerning: the synthesis of drugs and bioactive molecules; extraction of biologically active molecules from natural matrices and their qualitative-quantitative characterization by means of analytical techniques; the study of the structure-activity relationships, mechanism of action and the molecular basis of the behavioural effects of newly synthesized and/or naturally derived substances; the application of analytical methodologies for the recognition and dosage of drugs and toxicants; the nutraceutical studies of compounds, the formulation and development of traditional and innovative drug delivery systems, studies of characterization, stability and quality control of the final medicinal products.

More specifically, the learning objectives include:

  • rational design of bioactive molecules also applying computational methods, synthesis through advanced methods, analysis of molecules of biological interest, phytochemical applications;
  • synthesis and study of organic materials and biological compounds and characterization by spectroscopic techniques;
  • studies on the nutritional properties and chemical composition of food products and supplements; toxicological risk assessment;
  • in vivo, ex vivo and in vitro analysis of the molecular basis of the behavioural effects of newly synthesized, naturally derived and/or psychotropic substances;
  • preformulation, design, development, and control of the stability of conventional or innovative drug delivery systems; pharmacokinetics and metabolism studies.

Scholarships

Each PhD candidate is supported by scholarships funded by the Ministry of University and Research (MUR), including resources made available through the National Recovery and Resilience Plan (PNRR) or through co-funding by enterprises. In addition, according to Ministerial Decree 226/2021, at least 10% of the scholarship budget must be allocated to research activities. This budget, guaranteed by the supervisor, may cover the following expenses:

  • Purchase of equipment necessary for doctoral research activities
  • Purchase of consumable materials
  • Participation in conferences and seminars
  • Training courses and/or advanced training activities
  • Laboratory analysis services, including external services directly related to the doctoral research

Career Opportunities

The PhD students, at the end of the program, will obtain high competences in one of the above described investigational areas, a complete judgment autonomy, an adequate communication skill, a high ability to learn new information and apply new technologies to one of the listed research areas.

Therefore, they will be able to:

  • perform research activities in academia and research centers;
  • perform research and development activities in biomedical, environmental and pharmaceutical companies;
  • perform promotion and developmental activities regarding innovation technologies, new technology design and management in biomedical, environmental and pharmaceutical fields;
  • perform professional activities related to:
    • the study and understanding of biological phenomena at molecular, genetic and microbiologic level;
    • the regulated and incremental use of biotic resources in the environmental field;
    • the design and development new molecules and release systems in the pharmaceutical field;
    • carry out consultancy activities in the biomedical, environmental and pharmaceutical fields;
    • perform advice activities in biomedical, environmental and pharmaceutical fields.

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