Multifactorial pathogenesis of COVID-19-related coagulopathy. Can defibrotide have a role in the early phases of coagulation disorders?

Macciò, Antonio

Primo

;Madeddu, Clelia

Secondo

;Caocci, Giovanni

Penultimo

;La Nasa, Giorgio

Ultimo

2020-01-01

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Abstract

Thrombotic complications emerged as an important issue in patients with coronavirus disease 2019 (COVID-19). Consolidated reports regarding the clinical and laboratory findings in COVID-19 patients reveal thrombocytopenia, elevated D-dimer, prolonged prothrombin time, disseminated intravascular coagulation, and pulmonary intravascular coagulation (PIC). Recently, some authors emphasized the potential role of antiphospholipid antibodies in the pathogenesis of thrombotic events in patients with severe COVID-19.