Switch or swap strategy in rheumatoid arthritis patients failing TNF inhibitors? Results of a modified Italian Expert Consensus
Cauli, AlbertoMembro del Collaboration Group
;Mathieu, AlessandroMembro del Collaboration Group
;
2018-01-01
Abstract
Objective: To establish evidence-based and experts' opinion filtered statements on the optimal treatment choice between cycling (switch) and changing mode of action strategies (swap) in RA patients failing TNF inhibitors (TNFis).Methods: The relevant question (switch vs swap) was rephrased into a research question according to the population, intervention, comparison and outcome (PICO) strategy, considering all the available scientific evidence published from the 2013 EULAR set of recommendations up to mid-January 2016. Final statements derived from the retrieved scientific evidence and experts' consensus, with eventual rephrasing through a Delphi method during a national consensus of Italian rheumatologists.Results: From a total of 365 records, 12 studies were finally included. The final statements argued that, until head-to-head comparison data are available, switch and swap can be still considered suitable strategies in RA patients failing first TNFi, even though some data seem to lend more support to a different mode of action-targeted strategy.Conclusion: After failure of first TNFi course, switch and swap can be currently considered as alternative suitable approaches in RA patients.File | Dimensione | Formato | |
---|---|---|---|
2018 Todoerti et al Swich or swop in RA.pdf Solo gestori archivio
Tipologia: versione editoriale
Dimensione 162.5 kB
Formato Adobe PDF
|
162.5 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.