Opioid peptides: Structure-activity relationships of dermorphin endothiotetrapeptides. VII
BALBONI, GIANFRANCO;
1984-01-01
Abstract
We describe the synthesis and preliminary in vitro and in vivo pharmacological tests of five endothiotetrapeptide analogues of the opioid heptapeptide dermorphin H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser.-NH2. The modification obtained by substituting Phet for Phe3 or Glyt for Gly4 provided further analogues with significant opioid activity.Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.