University of Cagliari
Opioid peptides. Partially modified retro-inverso dermorphin analogues. XIII
BALBONI, GIANFRANCO;
1989-01-01
Abstract
We studied the effect of partial retro-inverso modification of a selected peptide bond of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) related peptides. The drastic loss of mu-receptor affinity following introduction of retro-inverso peptide bond between Phe1-D-Ala2 in the new peptide analogues, emphasized the importance of this backbone in the dermorphin peptides.
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