Promising inhibition of diabetes-related enzymes and antioxidant properties of Ptilostemon casabonae leaves extract
Sanna, CinziaFirst
;Fais, Antonella;Era, Benedetta;Delogu, Giovanna L;Sanna, Enrico;Dazzi, Laura;Rosa, Antonella;De Agostini, Antonio;Floris, Sonia
Penultimate
;Pintus, Francesca
Last
2023-01-01
Abstract
Type 2 diabetes (T2D) is a progressive metabolic disorder of glucose metabolism. One of the therapeutic approaches for the treatment of T2D is reducing postprandial hyperglycaemia through inhibition of the digestive enzymes α-glucosidase and α-amylase. In this context, aimed at identifying natural products endowed with anti-T2D potential, we focused on Ptilostemon casabonae (L.) Greuter, a species belonging to Asteraceae family. Enzymatic inhibition, antioxidant activity, phenolic composition and cellular assays were performed. This study revealed that the P. casabonae hydroalcoholic extract exerts a potent inhibitory activity against α-glucosidase. This activity is supported by an antioxidant effect, preventing ROS formation in a stressed cellular system. HPLC-PDA-MS/MS analysis, revealed a complex polyphenolic fraction. Among the tested pure compounds, 1,5-dicaffeoylquinic acid, apigenin and rutin displayed good α-glucosidase inhibitory activity. Our study suggested new potential of P. casabonae encouraging us to further testing the possible therapeutic potential of this extract.File | Size | Format | |
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2023_Ptilostemon casabonae_JEIMC.pdf open access
Type: versione editoriale
Size 2.36 MB
Format Adobe PDF
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2.36 MB | Adobe PDF | View/Open |
2023_Supplementary material_Ptilostemon casabonae_JEIMC.pdf open access
Description: Supplemental material
Type: versione editoriale
Size 430.41 kB
Format Adobe PDF
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430.41 kB | Adobe PDF | View/Open |
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