Nanocrystals as Tool to Enhance Stigmasterol Oral Bioavailability
Pireddu, RosaMember of the Collaboration Group
;Sinico, ChiaraMember of the Collaboration Group
;Ennas, GuidoMember of the Collaboration Group
;Valenti, DonatellaMember of the Collaboration Group
;Marongiu, FrancescaMember of the Collaboration Group
;Maria Fadda, AnnaMember of the Collaboration Group
;Schlich, Michele
Member of the Collaboration Group
;Lai, FrancescoMember of the Collaboration Group
2021-01-01
Abstract
Phytosterols are sterols naturally occurring in plant cells and well known for their cholesterollowering activity, as witnessed by the large number of food supplements based on these functional ingredients available on the market. However, the marked hydrophobic character of phytosterols makes their solubility in biological fluids extremely low, with disadvantageous consequences on the bioavailability and therapeutic efficacy. In this work, we explore the effect of particle size reduction on the water solubility of stigmasterol, one of the most abundant phytosterols, through the formulation of nanocystals. A robust, top-down production process was employed to prepare stigmasterol nanocrystals, subsequently characterized by thermal and spectroscopic techniques. When formulated as nanocrystals, the solubility of stigmasterol in water and in simulated gastro-intestinal fluids was boosted compared to the raw material. The increased solubility of stigmasterol nanocrystals makes such formulation a promising candidate for the development of medicinal/nutraceutical products with enhanced bioavailability.File | Size | Format | |
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