A previously undescribed variant of cutaneous clear-cell squamous cell carcinoma with psammomatous calcification and intratumoral giant cell granulomas
Rongioletti F.First
Writing - Original Draft Preparation
;Ferreli C.
Writing - Original Draft Preparation
;Atzori L.Member of the Collaboration Group
;Faa G.Penultimate
Member of the Collaboration Group
;Pilloni L.Last
Writing - Review & Editing
2021-01-01
Abstract
Cutaneous clear-cell squamous cell carcinoma (ccSCC) is a rare variant of SCC composed of clear cells that lack cytoplasmic glycogen or evidence of tricholemmal keratinization. We report a previously undescribed variant of ccSCC with psammomatous calcification and intratumoral giant cell granulomas. The differential diagnosis with trichilemmal carcinoma is outlined according to the criteria of the fourth edition of World Health Organization (WHO) classification. Our findings outline that psammomatous calcification may occur inside the keratinous pearls of the neoplastic lobules triggering an intratumoral giant cell granulomatous reaction. The prognostic significance of this histopathological presentation is unknown but the potential for formation of psammoma bodies in cSCC should be considered to avoid diagnostic pitfalls.File | Size | Format | |
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psammomatous scc.pdf Solo gestori archivio
Type: versione post-print
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