High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development
Pisano, Maria PaolaFirst
Writing - Original Draft Preparation
;Grandi, NicoleSecond
Writing - Review & Editing
;Tramontano, Enzo
Last
Project Administration
2020-01-01
Abstract
Human Endogenous retroviruses (HERVs) are remnants of ancient retroviral infections that represent a large fraction of our genome. Their transcriptional activity is finely regulated in early developmental stages and their expression is modulated in different cell types and tissues. Such activity has an impact on human physiology and pathology that is only partially understood up to date. Novel high-throughput sequencing tools have recently allowed for a great advancement in elucidating the various HERV expression patterns in different tissues as well as the mechanisms controlling their transcription, and overall, have helped in gaining better insights in an all-inclusive understanding of the impact of HERVs in biology of the host.File | Size | Format | |
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viruses-12-00633-v2.pdf open access
Description: Articolo principale
Type: versione post-print
Size 1.5 MB
Format Adobe PDF
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1.5 MB | Adobe PDF | View/Open |
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