Avocado-Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

Salehi, Bahare;Rescigno, Antonio

Second

Writing - Original Draft Preparation

;Dettori, Tinuccia

Writing - Original Draft Preparation

;Calina, Daniela;Docea, Anca Oana;Singh, Laxman;Cebeci, Fatma;Özçelik, Beraat;Bhia, Mohammed;Dowlati Beirami, Amirreza;Sharifi-Rad, Javad;Sharopov, Farukh;C Cho, William;Martins, Natália

2020-01-01

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Abstract

Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g., morphea, sclerodactyly, scleroderma in bands). Besides, it was reported that it can improve the mood and quality of life of postmenopausal women in reducing menopause-related symptoms. This article aims to summarize the studies on biological effects of the avocado-soybean unsaponifiable, its chemical composition, pharmacotherapy as well as applications in auto-immune, osteoarticular and menopausal disorders. Finally, we will also discuss on its safety, toxicological and regulatory practices.