Tocopherol-loaded transfersomes: in vitro antioxidant activity and efficacy in skin regeneration
C. CaddeoInvestigation
;M. L. Manca;A. M. Fadda;M. Manconi
2018-01-01
Abstract
Transfersomes were prepared by using different polysorbates (i.e., Tween 20, 40, 60 and 80) and loaded with tocopherol acetate, a naturally-occurring phenolic compound with antioxidant activity. The vesicles showed unilamellar morphology, small size (∼85 nm), low polydispersity index (≤0.27), and high entrapment efficiency, which increased as a function of the length of the Tween fatty acid chain (from 72% to 90%). The longterm stability of the formulations was evaluated by means of the Turbiscan™ technology, which indicated their good stability, irrespective of the Tween used. The vesicles efficiently delivered tocopherol to the skin, and showed biocompatibility in vitro in keratinocytes and fibroblasts. Regardless of the Tween used, the transfersomes were able to protect skin cells from the oxidative damage induced by hydrogen peroxide. Additionally, transfersomes promoted cell proliferation and migration, which resulted in an acceleration of skin wound closure. These results demonstrated that tocopherol-loaded transfersomes bear potential as topical delivery systemwith antioxidant activity and wound healing properties.File | Size | Format | |
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Caddeo et al 2018 tocopherol.pdf Solo gestori archivio
Type: versione editoriale
Size 3.08 MB
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3.08 MB | Adobe PDF | & nbsp; View / Open Request a copy |
Caddeo et al Manuscript_Pre-Print.pdf open access
Type: versione pre-print
Size 203.37 kB
Format Adobe PDF
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203.37 kB | Adobe PDF | View/Open |
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