PROM and labour effects on urinary metabolome: a pilot study
Francesco PalmasCo-prime
;Luigi BarberiniSecond
;MEREU, ROSSELLA;DEIANA, SARA FRANCESCA;FAIS, MARIA FRANCESCA;Antonio Noto;Claudia Fattuoni
;Angelica Dessì;Roberta Pintus;Vassilios FanosPenultimate
;Gian Benedetto MelisLast
2018-01-01
Abstract
Since pathologies and complications occurring during pregnancy and/or during labour may cause adverse outcomes for both newborns and mothers, there is a growing interest in metabolomic applications on pregnancy investigation. In fact, metabolomics has proved to be an efficient strategy for the description of several perinatal conditions. In particular, this study focuses on premature rupture of membranes (PROM) in pregnancy at term. For this project, urine samples were collected at three different clinical conditions: out of labour before PROM occurrence (Ph1), out of labour with PROM (Ph2), and during labour with PROM (Ph3). GC-MS analysis, followed by univariate and multivariate statistical analysis, was able to discriminate among the different classes, highlighting the metabolites most involved in the discrimination.File | Size | Format | |
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DiseaseMarkers2018.pdf open access
Type: versione editoriale
Size 1.56 MB
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1.56 MB | Adobe PDF | View/Open |
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