[Au(pyb-H)(mnt)]: A novel gold(III) 1,2-dithiolene cyclometalated complex with antimicrobial activity (pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate)
PINTUS, ANNAFirst
Member of the Collaboration Group
;ARAGONI, MARIA CARLAMember of the Collaboration Group
;MAIORE, LAURAMember of the Collaboration Group
;ISAIA, FRANCESCOMember of the Collaboration Group
;LIPPOLIS, VITOMember of the Collaboration Group
;ORRU, GERMANOMember of the Collaboration Group
;TUVERI, ENRICAMember of the Collaboration Group
;ARCA, MASSIMILIANO
Last
Member of the Collaboration Group
2017-01-01
Abstract
The novel heteroleptic cyclometalated complex [AuIII(pyb-H)(mnt)] (1; pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate) was tested against a panel of ten Gram positive (belonging to the Staphylococcus, Streptococcus spp. and Bacillus clausii), Gram negative (E. coli, K. pneumoniae, P. aeruginosa) bacteria and three yeasts belonging to the Candida spp. Complex 1 showed a remarkable bacteriostatic antimicrobial activity against staphylococci, with Minimum Inhibitory Concentration (MIC) values of 1.56 and 3.13 μg/mL for S. haemoliticus and S. aureus, respectively. Spectroscopic and electrochemical measurements, supported by Density Functional Theory (DFT) calculations, were exploited to fully investigate the electronic structure of complex 1 and its relationship with the antimicrobial activityFile | Size | Format | |
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