Study of a series of 8-substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE inhibitors
DI PETRILLO, AMALIA;PINTUS, FRANCESCA
2015-01-01
Abstract
In the current work we studied the interest of a series of 8-substitued 7-hydroxy-4-methylcoumarins as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. For the best compounds of the series, the IC50 value was determined. This work was based on previous results and is a preliminary screening for further design and synthesis of new derivatives as potential compounds that can modulate enzymatic systems involved in the neurodegenerative diseases.Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.