New Opioid Designed Multiple Ligand from Dmt-Tic and Morphinan Pharmacophores
BALBONI, GIANFRANCO
2006-01-01
Abstract
Here, we report the synthesis of a designed multi-pharmacophore ligand derived from the linkage of a delta selective peptide antagonist (Dmt-Tic) and a mu/kappa morphinan agonist butorphan (MCL 101) through a two methylene spacer. The new compound MCL 450 maintains the same characteristics as those the two reference compounds. MCL 450 represents a useful starting point for the synthesis of other multiple opioid ligands endowed with analgesic properties with low tolerance and dependence.Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.